De Bacquer D, Van Risseghem M, Clays E, Kittel F, De Backer G, Braeckman L
Department of Public Health, Ghent University, Belgium.
Int J Epidemiol. 2009 Jun;38(3):848-54. doi: 10.1093/ije/dyn360. Epub 2009 Jan 7.
Several studies have documented on the elevated cardiovascular risk among shift workers. In order to further explore this relation, we aimed at assessing the association between rotating shift work and the incidence of the metabolic syndrome (MetS).
In this population-based prospective study, 1529 employees from several large Belgian companies were followed for a median observation period of 6.6 years with respect to the onset of the MetS and its separate components.
At baseline, 309 men (20.2%) were rotating shift workers. The MetS incidence rate in these shift workers (60.6 per 1000 person-years) was increased in comparison with day workers (37.2 per 1000 person-years) with an odds ratio (95% CI) of 1.77 (1.34-2.32). Multivariate adjustment for potential lifestyle and work-related confounders did only marginally affect the strength of the association. The risk for the development of MetS gradually increased independently with accumulated years of shift work. Rotating shift work not only had an impact on MetS as a cluster of conditions but on each of its individual components as well.
Hence, prospective evidence was found that rotating shift work increases the risk for developing the MetS over a period of 6 years.
多项研究记录了轮班工作者心血管疾病风险升高的情况。为了进一步探究这种关系，我们旨在评估轮班工作与代谢综合征（MetS）发病率之间的关联。
在这项基于人群的前瞻性研究中，对来自几家比利时大公司的1529名员工进行了随访，中位观察期为6.6年，观察代谢综合征及其各个组分的发病情况。
在基线时，309名男性（20.2%）为轮班工作者。与日班工作者（每1000人年37.2例）相比，这些轮班工作者的代谢综合征发病率（每1000人年60.6例）有所升高，优势比（95%CI）为1.77（1.34 - 2.32）。对潜在生活方式和工作相关混杂因素进行多变量调整后，仅略微影响了关联强度。代谢综合征发生风险随着累积轮班工作年限的增加而逐渐独立升高。轮班工作不仅对作为一组病症的代谢综合征有影响，对其各个单独组分也有影响。
因此，有前瞻性证据表明，轮班工作会增加6年内发生代谢综合征的风险。
