Schettini Maria Alice Souza, Passos Rafael Feitosa do Nascimento, Koike Bruna Del Vechio
Department of Medicine, Medical School, Federal University of São Francisco Valley, Petrolina, PE, Brazil.
Sleep Sci. 2023 Jul 6;16(2):237-247. doi: 10.1055/s-0043-1770798. eCollection 2023 Jun.
Shift work can cause circadian cycles disturbances and misaligns the endogenous rhythms. The physiological variables are driven by the circadian system and, its misalignment, can impair the metabolic functions. Thus, the main objective of this study was to evaluate the metabolic alterations as a result of shift work and night work reported in articles published in the last 5 years, using the eligibility criteria both gender and indexed articles in English language. In order to execute this work, we perform a systematic review according to PRISMA guidelines and searched about Chronobiology Disorders and Night Work, both related to metabolism, in Medline, Lilacs, ScienceDirect and Cochrane. Cross-sectional, cohort and experimental studies with low risk of bias were included. We found a total of 132 articles, and, after the selection process, 16 articles remained to be analyzed. It was observed that shift work can cause circadian misalignment and, consequently, some metabolic parameters alterations such as an impaired glycemic control and insulin functioning, cortisol phase release, cholesterol fractions imbalance, changes in morphological indexes and melatonin secretion. There are some limitations, such as heterogenicity in used databases and the 5 years restriction period, because the effects of sleep disturbance may have been reported earlier. In conclusion, we suggest that shift work interferes with the sleep-wake cycle and eating patterns, which cause crucial physiological alterations that, together, can lead to metabolic syndrome.
轮班工作会导致昼夜节律紊乱，使内源性节律失调。生理变量受昼夜节律系统驱动，其失调会损害代谢功能。因此，本研究的主要目的是使用性别和英文索引文章的纳入标准，评估过去5年发表的文章中所报道的轮班工作和夜班工作导致的代谢改变。为了开展这项工作，我们根据PRISMA指南进行了系统综述，并在Medline、Lilacs、ScienceDirect和Cochrane数据库中搜索了与代谢相关的时间生物学紊乱和夜班工作。纳入了低偏倚风险的横断面研究、队列研究和实验研究。我们共找到132篇文章，经过筛选过程后，剩下16篇文章有待分析。观察到轮班工作会导致昼夜节律失调，进而导致一些代谢参数改变，如血糖控制受损、胰岛素功能异常、皮质醇相位释放、胆固醇组分失衡、形态学指标变化和褪黑素分泌改变。存在一些局限性，如所用数据库的异质性和5年的限制期，因为睡眠障碍的影响可能更早之前就已被报道。总之，我们认为轮班工作会干扰睡眠-觉醒周期和饮食模式，从而导致关键的生理改变，这些改变共同作用可能导致代谢综合征。
