Consoli Daniele, Contarino Angelo, Tabarin Antoine, Drago Filippo
Department of Experimental and Clinical Pharmacology, Medical School, University of Catania, Catania, Italy.
Int J Eat Disord. 2009 Jul;42(5):402-8. doi: 10.1002/eat.20637.
Given the lack of reliable murine model of binge-like eating, we tried to induce this pathological behavior in mice.
We used an experimental protocol mimicking the etiological factors involved in the development of binge eating in humans, that is, food restriction, refeeding (R-R) in presence of high palatable food, and stress (S).
Mice subjected to at least three cycles of R-R plus S (forced swimming stress), showed a binge-like behavior evident as early as 4 h, persisting 24 h after stress application and not associated to depressive-like behavior. However, after the third R-R/S cycle, food intakes of mice returned to normal levels.
(i) at least three cycles of R-R plus S are required to promote abnormal eating in mice, (ii) this is not associated to depressive-like behaviors, and (iii) the enhanced pathological behavior showed a transient nature not persisting after the third R-R/S cycle.
鉴于缺乏可靠的暴饮暴食小鼠模型,我们试图在小鼠中诱导这种病理行为。
我们采用了一种实验方案,模拟人类暴饮暴食发展过程中涉及的病因,即食物限制、在有高适口性食物的情况下重新喂食(R-R)以及应激(S)。
经历至少三个R-R加S周期(强迫游泳应激)的小鼠,早在4小时就表现出明显的暴饮暴食样行为,在施加应激后持续24小时,且与抑郁样行为无关。然而,在第三个R-R/S周期后,小鼠的食物摄入量恢复到正常水平。
(i)促进小鼠异常进食至少需要三个R-R加S周期,(ii)这与抑郁样行为无关,(iii)增强的病理行为表现出短暂性,在第三个R-R/S周期后不再持续。