Halpenny Darragh F, Burke John P, Lawlor Garrett O, O'Connell Martin
Department of Medicine, Mater Misericordiae University Hospital, Dublin, Ireland.
Inflamm Bowel Dis. 2009 Jun;15(6):951-8. doi: 10.1002/ibd.20817.
Positron emission tomography (PET) is a nuclear imaging technique providing noninvasive, three-dimensional, whole-body, quantitative images. The primary use of PET is in tumor detection and staging. More recently, it has been shown to be of value in assessing patients with inflammatory processes. To date the role of PET in the management of patients with inflammatory bowel disease (IBD) has not been defined.
The electronic literature (August 1966 to June 2008) on the utilization of PET in IBD was reviewed. Further references were obtained by cross-referencing from key articles.
There have been no randomized studies to date examining the role of PET in the management of patients with IBD. Comparative studies have demonstrated a high degree of correlation between PET-detected segmental (18)F-fluorodeoxyglucose uptake and sites of macroscopic and histological inflammation noted on endoscopy. Prospectively, PET performs favorably in comparison to conventional imaging modalities for IBD such as immunoscintigraphy, magnetic resonance imaging (MRI), and hydro-MRI. Several case series have highlighted the utility of PET in the diagnosis of IBD in the pediatric population. The recent development of PET/computed tomography (CT) combines the physiological sensitivity of PET with the anatomical accuracy of CT, increasing the specificity of PET.
The case series and nonrandomized studies published to date emphasize the utility of PET in assessing patients with IBD and justify further study. The development of PET/CT represents a significant advance and should be considered in the evaluation of patients with IBD.
正电子发射断层扫描（PET）是一种核成像技术，可提供无创、三维、全身定量图像。PET的主要用途是肿瘤检测和分期。最近，已证明其在评估炎症性疾病患者方面具有价值。迄今为止，PET在炎症性肠病（IBD）患者管理中的作用尚未明确。
回顾了1966年8月至2008年6月关于PET在IBD中应用的电子文献。通过对关键文章进行交叉引用获得了更多参考文献。
迄今为止，尚无随机研究探讨PET在IBD患者管理中的作用。比较研究表明，PET检测到的节段性（18）F-氟脱氧葡萄糖摄取与内镜检查中发现的宏观和组织学炎症部位之间存在高度相关性。前瞻性研究表明，与IBD的传统成像方式如免疫闪烁成像、磁共振成像（MRI）和水造影MRI相比，PET表现良好。几个病例系列突出了PET在儿科IBD诊断中的实用性。PET/计算机断层扫描（CT）的最新发展将PET的生理敏感性与CT的解剖准确性相结合，提高了PET的特异性。
迄今为止发表的病例系列和非随机研究强调了PET在评估IBD患者中的实用性，并证明有必要进一步研究。PET/CT的发展是一项重大进展，在IBD患者的评估中应予以考虑。
