Dancey Christine P, Attree Elizabeth A, Stuart George, Wilson Christine, Sonnet Amanda
School of Psychology, University of East London, London, UK.
Inflamm Bowel Dis. 2009 Jun;15(6):852-7. doi: 10.1002/ibd.20837.
Many chronic illnesses are accompanied by impaired cognitive functioning. In people with Inflammatory Bowel Disease (IBD), there is some research to suggest a decrement in verbal IQ (VIQ), when compared to people with Irritable Bowel Syndrome (IBS) and healthy controls. Although this is an important finding, it is necessary to ensure that such deficits are not due to methodological problems such as the failure to take into account pre-morbid functioning.
A total of 88 people (IBD, N = 29; IBS, N = 29; Controls, N = 30) completed the Wechsler Abbreviated Scale of Intelligence (WASI), the Wechsler Test of Adult Reading (WATR), the Trait Rumination Questionnaire (TRQ), the Center for Epidemiologic Studies Depression Scale (CES-D), and the General Health Questionnaire (GHQ-12).
We found evidence of a VIQ decrement in both IBD and IBS groups when measured against both healthy controls and against their own pre-morbid IQ scores (WTAR-Predicted WAIS-III IQ measures). However, the decrement was larger (and of clinical significance) in the IBD group but not in the IBS group.
Some tentative evidence is presented which suggests that poor VIQ performance may be due in part to interference from excessive rumination.
许多慢性疾病都伴有认知功能受损。在炎症性肠病（IBD）患者中，有一些研究表明，与肠易激综合征（IBS）患者和健康对照相比，其言语智商（VIQ）有所下降。尽管这是一项重要发现，但有必要确保此类缺陷并非由于未考虑病前功能等方法学问题所致。
共有88人（IBD组，N = 29；IBS组，N = 29；对照组，N = 30）完成了韦氏简式智力量表（WASI）、韦氏成人阅读测验（WATR）、特质沉思问卷（TRQ）、流行病学研究中心抑郁量表（CES-D）和一般健康问卷（GHQ-12）。
我们发现，与健康对照以及各自病前智商分数（WTAR预测的WAIS-III智商测量值）相比，IBD组和IBS组均存在VIQ下降的证据。然而，IBD组的下降幅度更大（且具有临床意义），而IBS组则不然。
提出了一些初步证据，表明VIQ表现不佳可能部分归因于过度沉思的干扰。
