长期使用肉毒杆菌毒素治疗喉肌张力障碍患者的剂量变化。
Dosage changes in patients with long-term botulinum toxin use for laryngeal dystonia.
作者信息
Birkent Hakan, Maronian Nicole, Waugh Patricia, Merati Albert L, Perkel David, Hillel Allen D
机构信息
Department of Otolaryngology-Head & Neck Surgery, Gulhane Military Medical Academy, Ankara, Turkey.
出版信息
Otolaryngol Head Neck Surg. 2009 Jan;140(1):43-7. doi: 10.1016/j.otohns.2008.10.033.
OBJECTIVE
To investigate the dosage consistency of botulinum toxin injections in patients with long-term treatment for laryngeal dystonia.
STUDY DESIGN
Chart review.
SUBJECTS AND METHODS
Patients with laryngeal dystonia who had received at least 20 injections to the thyroarytenoid muscle were selected. Change of botulinum toxin dose, patient-reported effective weeks, and intervals between injections were investigated; data from the first five injections were excluded to eliminate initial dose titration.
RESULTS
Fifty-five patients with an average follow-up of 12.5 years were identified. Mean dose of botulinum toxin was 2.37 +/- 1.6 U at the sixth injection; there was a decrease in mean dose over time, which became statistically significant at the 13th injection with a mean dose of 2.02 +/- 1.16 U. Mean duration of good effect and treatment intervals showed no significant change over time.
CONCLUSION
Botulinum toxin dose needed for a constant response in treatment of laryngeal dystonia decreases over time, without any accompanying change in effective weeks and intervals.
目的
探讨长期接受肉毒杆菌毒素注射治疗喉肌张力障碍患者的剂量一致性。
研究设计
病历回顾。
研究对象与方法
选取接受过至少20次甲状杓肌注射的喉肌张力障碍患者。研究肉毒杆菌毒素剂量的变化、患者报告的有效周数以及注射间隔时间；排除前五次注射的数据以消除初始剂量滴定的影响。
结果
共确定55例患者，平均随访12.5年。第六次注射时肉毒杆菌毒素的平均剂量为2.37±1.6单位；随着时间推移平均剂量有所下降，在第13次注射时平均剂量为2.02±1.16单位，差异具有统计学意义。良好效果的平均持续时间和治疗间隔时间随时间无显著变化。
结论
治疗喉肌张力障碍时维持恒定反应所需的肉毒杆菌毒素剂量随时间减少，但有效周数和间隔时间无相应变化。
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