Magro Gaetano, Emmanuele Carmela, Lopes Maria, Vallone Giuseppe, Greco Paolo
Dipartimento G.F. Ingrassia, Policlinico Universitario G. Rodolico, Anatomia Patologica, Università di Catania, Catania, Italy.
APMIS. 2008 Nov;116(11):1020-5. doi: 10.1111/j.1600-0463.2008.01012.x.
Solitary fibrous tumour (SFT) rarely occurs in the kidney, with only one case exhibiting malignant behaviour. We report the case of a typical SFT of the kidney with sarcomatous overgrowth in a 34-year-old woman. This malignant component, grossly apparent as a nodular area arising in the context of the main tumour mass, consisted of CD34+ mitotically active atypical plump spindle- to epithelioid-shaped cells, including pleomorphic multinucleated giant cells. A novel immunohistochemical finding was diffuse and strong S-100 protein expression by sarcomatous cells. This should be kept in mind by pathologists to avoid confusion with other S-100 protein-positive malignant neoplasms.
孤立性纤维瘤（SFT）很少发生于肾脏，仅有1例表现出恶性行为。我们报告1例34岁女性典型的肾脏SFT伴肉瘤样过度生长的病例。该恶性成分肉眼上表现为主要肿瘤块内出现的一个结节状区域，由CD34阳性、有丝分裂活跃的非典型丰满梭形至上皮样细胞组成，包括多形性多核巨细胞。一个新的免疫组化发现是肉瘤样细胞弥漫性且强表达S-100蛋白。病理学家应牢记这一点，以避免与其他S-100蛋白阳性恶性肿瘤混淆。
