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钙信号传导对可变剪接调控的影响。

The influence of calcium signaling on the regulation of alternative splicing.

作者信息

Krebs Joachim

机构信息

NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.

出版信息

Biochim Biophys Acta. 2009 Jun;1793(6):979-84. doi: 10.1016/j.bbamcr.2008.12.006. Epub 2008 Dec 24.

DOI:10.1016/j.bbamcr.2008.12.006
PMID:19133299
Abstract

In this review the influence of calcium signaling on the regulation of alternative splicing is discussed with respect to its influence on cell- and developmental-specific expression of different isoforms of the plasma membrane calcium pump (PMCA). In a second part the possibility is discussed that due to the interaction of the calcium-binding protein ALG-2 with a spliceosomal regulator of alternative splicing, RBM22, Ca2+-signaling may thus influence its regulatory property.

摘要

在本综述中，我们讨论了钙信号传导对可变剪接调控的影响，具体涉及它对质膜钙泵（PMCA）不同异构体的细胞特异性和发育特异性表达的影响。在第二部分中，我们讨论了一种可能性，即由于钙结合蛋白ALG-2与可变剪接的剪接体调节因子RBM22相互作用，Ca2+信号传导可能因此影响其调节特性。

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