NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Goettingen, Germany.
Neurochem Res. 2011 Jul;36(7):1198-211. doi: 10.1007/s11064-011-0431-4. Epub 2011 Mar 2.
Ca(2+)-signaling, alternative splicing, and stress responses by the endoplasmic reticulum are three important cellular activities which can be strongly interconnected to alter the expression of protein isoforms in a tissue dependent manner or during development depending on the environmental conditions. This integrated network of signaling pathways permits a high degree of versatility and adaptation to metabolic, developmental and stress processes. Defects in its regulation may lead to cellular malfunction.
内质网钙离子信号转导、选择性剪接和应激反应是三种重要的细胞活动，它们可以通过强烈的相互作用，根据组织依赖性或发育过程中的环境条件改变蛋白质异构体的表达。这种信号通路的集成网络允许高度的多功能性和适应性，以适应代谢、发育和应激过程。其调节的缺陷可能导致细胞功能障碍。
