Hoffer Melissa J, Griffon Dominique J, Schaeffer David J, Johnson Ann L, Thomas Michael W
University of Illinois Veterinary Teaching Hospital, Urbana, IL 61802, USA.
Vet Surg. 2008 Oct;37(7):639-47. doi: 10.1111/j.1532-950X.2008.00430.x.
To evaluate the outcome in dogs treated with demineralized bone matrix (DBM) as an adjunct to orthopedic procedures.
Retrospective and case-match study.
Dogs (n=75).
Medical records (1999-2006) and radiographs of dogs that had orthopedic procedures (comminuted fractures, tibial plateau leveling osteotomy [TPLO] where correction for tibial rotation created an osteotomy gap, arthrodeses, open corrective osteotomies) where DBM was used were reviewed for signalment, quantity of DBM implanted, duration of exercise restriction, radiographic healing, and complications. Dogs that had TPLO and correction of tibial torsion (n=15), or arthrodesis (n=16) were compared with case-matched controls. Data were analyzed using Kruskal-Wallis test, ANOVA, Tukey's HSD test, and logistic regression analysis.
Mean (+/-SD) healing time for orthopedic surgeries with DBM augmentation were 15+/-6.97 (weeks) and complication rate was 19% (14 dogs). Dogs with a TPLO gap filled with DBM were allowed to return to normal exercise 2 weeks earlier than dogs with a well-apposed TPLO site. Radiographic healing, duration of exercise restriction, and timing of destabilization were similar in dogs undergoing carpal and tarsal arthrodesis whether they received DBM, autogenous graft, or both.
DBM can be used to treat uncomplicated bone defects associated with comminuted fracture repairs, open osteotomies, and arthrodeses in dogs. Under these circumstances, clinicians might expect similar clinical outcomes without the possibility of side effects associated with the harvest of autogenous cancellous bone.
DBM is safe for use in dogs.
评估用脱矿骨基质（DBM）辅助骨科手术治疗犬的效果。
回顾性病例对照研究。
犬（n = 75）。
回顾1999年至2006年接受骨科手术（粉碎性骨折、胫骨平台水平截骨术[TPLO]，其中胫骨旋转矫正产生截骨间隙、关节融合术、开放性矫正截骨术）并使用DBM的犬的病历和X光片，以了解其特征、植入DBM的量、运动限制的持续时间、影像学愈合情况及并发症。将接受TPLO和胫骨扭转矫正的犬（n = 15）或关节融合术的犬（n = 16）与病例匹配的对照组进行比较。使用Kruskal-Wallis检验、方差分析、Tukey's HSD检验和逻辑回归分析对数据进行分析。
使用DBM增强的骨科手术的平均（±标准差）愈合时间为15±6.97（周），并发症发生率为19%（14只犬）。填充DBM的TPLO间隙的犬比TPLO部位对位良好的犬提前2周恢复正常运动。接受腕关节和跗关节融合术的犬，无论是否接受DBM、自体移植物或两者，其影像学愈合、运动限制持续时间和去稳定时间相似。
DBM可用于治疗犬与粉碎性骨折修复、开放性截骨术和关节融合术相关的单纯性骨缺损。在这些情况下，临床医生可能期望获得相似的临床结果，且不会有与自体松质骨采集相关的副作用。
DBM用于犬是安全的。
