Szponder Tomasz, Wessely-Szponder Joanna, Sobczyńska-Rak Aleksandra, Żylińska Beata, Radzki Radosław P, Polkowska Izabella
Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland
Department of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland.
In Vivo. 2018 Nov-Dec;32(6):1449-1455. doi: 10.21873/invivo.11398.
To assess the applicability of β-tri-calcium phosphate (TCP) and platelet-rich plasma (PRP) in the treatment of comminuted fractures in small animals.
The experimental study was carried out on 16 New Zealand White rabbits. After creating the bone defect and performing tibial osteotomy, TCP implants containing activated PRP were introduced into the fracture and the defect. The fracture was stabilised using external fixators or intramedullary nails. After 12 weeks, the animals were euthanised, and radiological, histological, scanning electron microscopy and peripheral quantitative computed tomography examinations were performed. The analysis also covered the results of fracture treatment in 37 small animals (cats and dogs) in which treatment with TCP containing PRP was used as an alternative to cancellous bone implantation.
Correct bone union was observed in the experimental groups, TCP remained visible at the site of the fracture after 12 weeks. In the clinical application in small animals, bone union was observed in over 91% of treated animals.
β-TCP and activated PRP may be an effective method of bone union enhancement in the treatment of comminuted fractures in small animals.
评估β-磷酸三钙（TCP）和富血小板血浆（PRP）在小动物粉碎性骨折治疗中的适用性。
对16只新西兰白兔进行实验研究。制造骨缺损并进行胫骨截骨后，将含有活化PRP的TCP植入物植入骨折部位和缺损处。使用外固定器或髓内钉固定骨折。12周后，对动物实施安乐死，并进行放射学、组织学、扫描电子显微镜和外周定量计算机断层扫描检查。分析还涵盖了37只小动物（猫和狗）的骨折治疗结果，其中使用含PRP的TCP治疗替代松质骨植入。
实验组观察到正确的骨愈合，12周后骨折部位仍可见TCP。在小动物的临床应用中，超过91%的治疗动物观察到骨愈合。
β-TCP和活化PRP可能是增强小动物粉碎性骨折骨愈合的有效方法。
