Verallo-Rowell Vermén M, Dillague Kristine M, Syah-Tjundawan Bertha S
Skin and Cancer Foundation, Pasig, Philippines.
Dermatitis. 2008 Nov-Dec;19(6):308-15.
Atopic dermatitis (AD) skin is dry and readily colonized by Staphylococcus aureus (SA). Coconut and olive oils are traditionally used to moisturize and treat skin infections.
To compare virgin coconut oil (VCO) and virgin olive oil (VOO) in moisturizing dryness and removing SA from colonized AD skin.
This was a double-blind controlled trial in two outpatient dermatology clinics with adult AD patients who were diagnosed by history, pattern, evolution, and skin lesions and who were randomized to apply VCO or VOO twice daily at two noninfected sites. SA cultures, photography, and objective-SCORAD severity index (O-SSI) scoring were done at baseline and after 4 weeks.
Twenty-six subjects each received VCO or VOO. Of those on VCO, 20 were positive for SA colonies at baseline versus 12 on VOO. Post intervention, only 1 (5%) VCO subject remained positive versus 6 (50%) of those on VOO. Relative risk for VCO was 0.10, significantly superior to that for VOO (10:1, p = .0028; 95% CI, 0.01-0.73); thus, the number needed to treat was 2.2. For the O-SSI, the difference was not significant at baseline (p = .15) but was significantly different post treatment (p = .004); this was reduced for both oils (p < .005) but was greater with VCO.
VCO and monolaurin's O-SSI reduction and in vitro broad-spectrum activity against SA (given clinical validity here), fungi, and viruses may be useful in the proactive treatment of AD colonization.
特应性皮炎（AD）患者的皮肤干燥，且易被金黄色葡萄球菌（SA）定植。传统上，椰子油和橄榄油用于滋润皮肤并治疗皮肤感染。
比较初榨椰子油（VCO）和初榨橄榄油（VOO）对AD定植皮肤干燥的保湿效果以及清除SA的能力。
这是一项双盲对照试验，在两家门诊皮肤科诊所对成年AD患者进行研究。这些患者通过病史、症状表现、病情发展和皮肤损害进行诊断，并随机分配至两个未感染部位，每天两次涂抹VCO或VOO。在基线期和4周后进行SA培养、拍照以及客观SCORAD严重程度指数（O-SSI）评分。
26名受试者分别接受VCO或VOO治疗。在接受VCO治疗的受试者中，20人在基线期SA菌落检测呈阳性，而接受VOO治疗的为12人。干预后，接受VCO治疗的受试者中只有1人（5%）仍为阳性，而接受VOO治疗的有6人（50%）。VCO的相对风险为0.10，显著优于VOO（10:1，p = 0.0028；95%置信区间，0.01 - 0.73）；因此，治疗所需人数为2.2。对于O-SSI，基线期差异不显著（p = 0.15），但治疗后差异显著（p = 0.004）；两种油类的该指标均有所降低（p < 0.005），但VCO降低幅度更大。
VCO和月桂酸单甘油酯降低O-SSI以及对SA（鉴于此处的临床有效性）、真菌和病毒的体外广谱活性，可能有助于AD定植的主动治疗。
