Ahmed Mohamed, Griffin Damian, O'Toole Ray, McDonald Colm
Department of Psychiatry, National University of Ireland Galway, Galway, Ireland.
Gen Hosp Psychiatry. 2009 Jan-Feb;31(1):93-6. doi: 10.1016/j.genhosppsych.2008.07.003. Epub 2008 Sep 5.
To highlight the association between the use of clozapine and the early development of severe mixed hyperlipidemia, a condition that substantially increases the risk of cardiovascular events and other medical complications.
Clinical information and data from investigations in a single patient were collated and reviewed in light of the literature.
A 47-year-old man with a background history of schizophrenia taking clozapine presented with multiple episodes of severe elevation of serum triglycerides and cholesterol with subsequent development of diabetes mellitus. His metabolic parameters normalized following discontinuation of clozapine.
Lipid and metabolic profiles should be closely monitored in patients receiving clozapine in order to facilitate early detection and intervention to prevent further health complications.
强调使用氯氮平与严重混合型高脂血症早期发生之间的关联，这种情况会大幅增加心血管事件及其他医学并发症的风险。
根据文献对一名患者的临床信息和调查数据进行整理和回顾。
一名47岁患有精神分裂症且正在服用氯氮平的男性，出现多次血清甘油三酯和胆固醇严重升高的情况，随后发展为糖尿病。停用氯氮平后，他的代谢参数恢复正常。
接受氯氮平治疗的患者应密切监测血脂和代谢情况，以便早期发现并进行干预，预防进一步的健康并发症。
