Kotru Mrinalini, Batra Madhu, Gomber Sunil, Rusia Usha
Department of Pathology, University College of Medical Sciences and Associated Guru Teg Bahadur Hospital, New Delhi - 110 095, India.
Indian J Pathol Microbiol. 2009 Jan-Mar;52(1):113-4. doi: 10.4103/0377-4929.44992.
Thrombocytosis is commonly seen in reactive conditions and certain neoplastic states, such as chronic myeloproliferative disorders. It is rarely seen in acute leukemia. A 12-year-old girl with acute myeloblastic leukemia (FAB M2) in remission presented with pyoderma. Her hemogram revealed anemia (Hb-6.4g/dl), leucopenia (TLC - 1.2 x 109/L) and thrombocytosis (platelet count- 580 x 109/L). A peripheral blood film showed numerous abnormally large platelets with few atypical cells. The thrombocytosis subsided with the clearance of infection but atypical cells persisted. One month later, she relapsed. Cytogenetic analysis revealed variable results (trisomy 9 and deletion 3). This case has been presented because thrombocytosis is rare in AML and its appearance calls for a close follow-up.
血小板增多常见于反应性疾病和某些肿瘤状态，如慢性骨髓增殖性疾病。在急性白血病中很少见。一名缓解期的12岁急性髓细胞白血病（FAB M2型）女孩出现脓疱病。她的血常规显示贫血（血红蛋白-6.4g/dl）、白细胞减少（白细胞计数-1.2×10⁹/L）和血小板增多（血小板计数-580×10⁹/L）。外周血涂片显示有许多异常大的血小板和少量非典型细胞。随着感染的清除，血小板增多症消退，但非典型细胞持续存在。一个月后，她复发了。细胞遗传学分析结果不一（9号染色体三体和3号染色体缺失）。之所以呈现这个病例，是因为血小板增多在急性髓细胞白血病中罕见，其出现需要密切随访。
