Grandemange Stéphanie, Herzig Sébastien, Martinou Jean-Claude
Department of Cell Biology, University of Geneva, Switzerland.
Semin Cancer Biol. 2009 Feb;19(1):50-6. doi: 10.1016/j.semcancer.2008.12.001. Epub 2008 Dec 24.
Mitochondrial morphology is regulated by continuous fusion and fission events that are essential for maintaining a normal mitochondrial function. If the last years have witnessed major discoveries in the characterization of the fission and fusion machineries, little is known about the physiological role of mitochondrial dynamics. In this review we report the results showing evidences of relationships between mitochondrial dynamics and cellular metabolism, autophagy or apoptosis. We discuss how different mitochondrial alterations observed in cancer cells could be linked to unbalanced mitochondrial fission or fusion events and how this could impinge on key essential cellular processes, thereby contributing to tumorigenesis.
线粒体形态由持续的融合和分裂事件调控，这些事件对于维持正常的线粒体功能至关重要。尽管在过去几年中，线粒体分裂和融合机制的特征方面有了重大发现，但对于线粒体动力学的生理作用却知之甚少。在本综述中，我们报告了一些结果，这些结果显示了线粒体动力学与细胞代谢、自噬或凋亡之间存在关联的证据。我们讨论了在癌细胞中观察到的不同线粒体改变如何与线粒体分裂或融合事件失衡相关联，以及这如何影响关键的基本细胞过程，从而促进肿瘤发生。
