海洋天然产物。二十六。来自冲绳海洋海绵斯氏海绵（斯氏海绵科）的具有生物活性的十三肽内酯。(2). 斯氏海绵肽内酯Ia、Ib、Ic和Ie的结构。
Marine natural products. XXVI. Biologically active tridecapeptide lactones from the Okinawan marine sponge Theonella swinhoei (Theonellidae). (2). Structures of theonellapeptolides Ia, Ib, Ic, and Ie.
作者信息
Kobayashi M, Lee N K, Shibuya H, Momose T, Kitagawa I
机构信息
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1991 May;39(5):1177-84. doi: 10.1248/cpb.39.1177.
Five tridecapeptide lactones, named theonellapeptolides Ia (1), Ib (2), Ic (3), Id (4), and Ie (5), were isolated from the Okinawan marine sponge Theonella swinhoei. Following the structure elucidation of theonellapeptolide Id (4), the structures of theonellapeptolides Ia (1), Ib (2), Ic (3), and Ie (5) were determined on the basis of chemical and physicochemical evidence including high performance liquid chromatography and circular dichroism combined analysis of the amino acid compositions. Theonellapeptolides Ib (2), Ic (3), Id (4), and Ie (5) exhibit moderate cytotoxic activity towards for L1210 in vitro (IC50 1.6, 1.3, 2.4, and 1.4 micrograms/ml, respectively), and theonellapeptolide Ie (5) exhibits ion-transport activities for Na+ and K+ ions.
从冲绳海洋海绵斯氏海绵（Theonella swinhoei）中分离出了五种十三肽内酯，分别命名为theonellapeptolides Ia（1）、Ib（2）、Ic（3）、Id（4）和Ie（5）。在确定了theonellapeptolide Id（4）的结构之后，基于包括高效液相色谱和氨基酸组成的圆二色光谱联合分析等化学和物理化学证据，确定了theonellapeptolides Ia（1）、Ib（2）、Ic（3）和Ie（5）的结构。Theonellapeptolides Ib（2）、Ic（3）、Id（4）和Ie（5）在体外对L1210表现出中等程度的细胞毒性活性（IC50分别为1.6、1.3、2.4和1.4微克/毫升），并且theonellapeptolide Ie（5）对Na+和K+离子表现出离子转运活性。
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