海洋天然产物。三十三。西奥内拉肽II d，一种从冲绳海洋海绵斯氏海绵中分离出的新型十三肽内酯。

Marine natural products. XXXIII. Theonellapeptolide IId, a new tridecapeptide lactone from the Okinawan marine sponge Theonella swinhoei.

作者信息

Kobayashi M, Kanzaki K, Katayama S, Ohashi K, Okada H, Ikegami S, Kitagawa I

机构信息

Faculty of Pharmaceutical Sciences, Osaka University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1994 Jul;42(7):1410-5. doi: 10.1248/cpb.42.1410.

DOI:10.1248/cpb.42.1410

PMID:7923463

Abstract

Following the characterization of theonellapeptolides Ia-Ie (2-6), another new tridecapeptide lactone named theonellapeptolide IId (1) was isolated from the Okinawan marine sponge Theonella swinhoei. The structure of 1 has been determined on the bases of chemical and physicochemical examinations which included an HPLC-CD combined analysis of the amino acid composition. Theonellapeptolide IId (1) prevented fertilization of the sea urchin Hemicentrotus pulcherrimus at the concentration of 25 micrograms/ml or greater but did not affect early embryonic development of fertilized eggs up to the gastrula stage.

摘要

在对西奥内拉肽Ia - Ie（2 - 6）进行表征之后，从冲绳海洋海绵斯氏海绵（Theonella swinhoei）中分离出了另一种名为西奥内拉肽IId（1）的新型十三肽内酯。通过化学和物理化学检测确定了1的结构，这些检测包括对氨基酸组成的高效液相色谱 - 圆二色光谱联用分析。西奥内拉肽IId（1）在浓度为25微克/毫升或更高时可阻止海胆光棘球海胆（Hemicentrotus pulcherrimus）受精，但对受精卵直至原肠胚阶段的早期胚胎发育没有影响。