Zeng Q F, Xu J H
Department of Pathology, Hunan Medical University, Changsha.
Zhonghua Bing Li Xue Za Zhi. 1991 Jun;20(2):107-9.
The relationships among estrogen receptor (ER), progesterone receptor (PgR) and glucose-6-phosphate dehydrogenase (G6PD) activity demonstrated by histochemical technique were studied in 85 cases of primary breast cancer. The ER positive rate was 71.8% and the PgR positive rate was 54.1%. A close correlation was obtained between the PgR and ER positivity or the semiquantitative grades. The G6PD activity in ER or PgR positive group was higher than that in the negative group. Moreover, the elevated G6PD activity was also correlated with the increased semiquantitative grades of ER or PgR. Our findings support the views that both PgR and G6PD are proteins induced by estrogen and may represent markers of functional ER in breast cancer. This suggests that simultaneous assay of ER, PgR and/or G6PD activity may be more reliable to predict the hormone dependence of the tumor.
采用组织化学技术研究了85例原发性乳腺癌中雌激素受体（ER）、孕激素受体（PgR）与葡萄糖-6-磷酸脱氢酶（G6PD）活性之间的关系。ER阳性率为71.8%，PgR阳性率为54.1%。PgR与ER阳性或半定量分级之间存在密切相关性。ER或PgR阳性组的G6PD活性高于阴性组。此外，G6PD活性升高也与ER或PgR半定量分级增加相关。我们的研究结果支持以下观点：PgR和G6PD都是雌激素诱导的蛋白质，可能代表乳腺癌中功能性ER的标志物。这表明同时检测ER、PgR和/或G6PD活性可能更可靠地预测肿瘤的激素依赖性。
