Effi Ahoua Benjamin, Aman Nguiessan Alphonse, Koui Baumaney Sylvanus, Koffi Kouadio Donatien, Traoré Zie Cheick, Kouyate Mohamed
Department of Anatomic Pathology, School of Medicine, Alassane Ouattara University, BP V 18, Bouake, Ivory Coast.
Department of Anatomic Pathology, Treichville Teaching Hospital, 01 BP V 03, Abidjan 01, Ivory Coast.
BMC Cancer. 2017 Feb 7;17(1):115. doi: 10.1186/s12885-017-3105-z.
Breast cancer is a heterogeneous and a hormone-dependent disease. The detection of the estrogen receptor (ER) and progesterone receptor (PgR) is crucial for prognostic evaluation and treatment choice of breast cancer for clinical practice. The purpose of this study was to evaluate the expression of the hormonal receptors, their distribution, and their correlation with clinicopathologic prognostic parameters for the improvement of the patients' treatment in Ivory Coast.
The 20-month prospective study included 302 patients who were diagnosed with primary invasive breast carcinomas at the Central Laboratory in Abidjan. The paraffin-embedded blocks of these patients were examined by immunohistochemistry to assess the ER and PgR status. The one-way analysis of variance and Chi-Square Test were used to analyze the data.
The mean age of patients at diagnosis was 48 ± 11 years. The majority of the women were premenopausal in 180 cases (59.9%). The predominant histologic type was invasive ductal carcinoma not otherwise specified (IDC NOS) in 247 cases (82%). Tumor grade 2 was more frequent in 166 cases (55%). Among 302 patients, 169 (56%) and 154 (49%) expressed ER and PgR respectively. The ER+PgR+ group with 131 cases (43%) was predominant, followed by 116 cases (38%) of ER-PgR-. The expression of ER and PgR was correlated with the age of the patients (p = 0.026) and the tumor grade (p = 0.0004). However, there was not statistically significant correlation between ER/PgR and the menopausal status of patients (p = 0.149), nor between ER/PgR and the histologic type (p = 0.523).
The ER+PgR+ and ER-PgR- are the most common subgroups in women with breast cancer in Ivory Coast. The hormonal receptor status is associated with the age and the histologic grade in breast cancer patients. The systematic use of hormonal treatment should be reevaluated. A further study should be done to investigate the reasons of high rate of ER-PgR- in breast cancer patients in Ivory Coast.
乳腺癌是一种异质性的激素依赖性疾病。雌激素受体（ER）和孕激素受体（PgR）的检测对于乳腺癌临床实践中的预后评估和治疗选择至关重要。本研究的目的是评估激素受体的表达、分布及其与临床病理预后参数的相关性，以改善科特迪瓦患者的治疗。
这项为期20个月的前瞻性研究纳入了302例在阿比让中央实验室被诊断为原发性浸润性乳腺癌的患者。通过免疫组织化学检查这些患者的石蜡包埋组织块，以评估ER和PgR状态。采用单因素方差分析和卡方检验分析数据。
患者诊断时的平均年龄为48±11岁。180例（59.9%）女性为绝经前状态。主要组织学类型为非特殊类型浸润性导管癌（IDC NOS），共247例（82%）。肿瘤2级更为常见，共166例（55%）。在302例患者中，分别有169例（56%）和154例（49%）表达ER和PgR。ER+PgR+组占主导，共131例（43%），其次是ER-PgR-组，共116例（38%）。ER和PgR的表达与患者年龄相关（p = 0.026），与肿瘤分级相关（p = 0.0004）。然而，ER/PgR与患者绝经状态之间无统计学显著相关性（p = 0.149），与组织学类型之间也无相关性（p = 0.523）。
ER+PgR+和ER-PgR-是科特迪瓦乳腺癌女性中最常见的亚组。激素受体状态与乳腺癌患者的年龄和组织学分级相关。应重新评估激素治疗的系统应用。应进一步开展研究，以探究科特迪瓦乳腺癌患者中ER-PgR-比例较高的原因。
