Mason D H, Takemoto K K
Int J Cancer. 1977 Mar 15;19(3):391-5. doi: 10.1002/ijc.2910190317.
Primary rabbit kidney cells were transformed by BKV(MM), a papovavirus isolated from the urine of a child with the Wiskott-Aldrich syndrome. The transformed cells contained BK T-antigen, but no antigen that reacted with SV40 U-antiserum. The transformed cells failed to produce tumors in nude mice, and BKV (MM) was not rescued from transformed cells by cell fusion or chemical induction methods. The transformed cells supported the growth of rabbit kidney vacuolating virus (RKV), and could be used to quantitate RKV by plaque formation under an agar overlay.
原代兔肾细胞被BKV(MM)转化，BKV(MM)是一种从患有维斯科特-奥尔德里奇综合征的儿童尿液中分离出的乳头多瘤空泡病毒。转化后的细胞含有BK T抗原，但没有与SV40 U抗血清发生反应的抗原。转化后的细胞在裸鼠中不能产生肿瘤，并且不能通过细胞融合或化学诱导方法从转化细胞中拯救出BKV(MM)。转化后的细胞支持兔肾空泡化病毒(RKV)的生长，并且可用于通过在琼脂覆盖物下形成噬斑来定量RKV。
