Rziha H J, Belohradsky B H, Schneider U, Schwenk H U, Bornkamm G W, zur Hausen H
Med Microbiol Immunol. 1978 Jul 4;165(2):83-92. doi: 10.1007/BF02122743.
Sera of 451 children with congenital diseases and 185 tumor patients were tested for BK virus-specific antibodies by hemagglutination inhibition and IgM-immunofluorescence tests. Compared to age-matched control groups, higher percentages and significantly elevated geometric mean titers of HI antibodies were found in all patient groups tested. Of children under six months of age with congenital diseases such as dysplasia, cerebral defects, and hyperbilirubinemia and hepatosplenomegaly, 4.2% (17/402) had BK virus-specific IgM antibodies. No positive sera were found in 68 control sera. Of tumor patients 5--15 years of age, 8.6% (16/185) had IgM antibodies to BK virus. In the control group, 30% (3/99) had them. Serial serum samples from 76 tumor patients treated with cytostatic drugs showed seroconversion in three cases. No relationship between certain clinical features and BK virus infection was noted. Isolation of BK virus was successful from urines of two infants with connatal defects, six patients suffering from malignant tumors, and four patients with inherited immunodeficiencies.
通过血凝抑制试验和IgM免疫荧光试验，对451名患有先天性疾病的儿童和185名肿瘤患者的血清进行了BK病毒特异性抗体检测。与年龄匹配的对照组相比，在所有受试患者组中，血凝抑制抗体的百分比更高，几何平均滴度显著升高。在患有发育不良、脑缺陷、高胆红素血症和肝脾肿大等先天性疾病的6个月以下儿童中，4.2%（17/402）有BK病毒特异性IgM抗体。在68份对照血清中未发现阳性血清。在5至15岁的肿瘤患者中，8.6%（16/185）有针对BK病毒的IgM抗体。在对照组中，30%（3/99）有此类抗体。76名接受细胞抑制药物治疗的肿瘤患者的系列血清样本显示，有3例出现血清转化。未发现某些临床特征与BK病毒感染之间存在关联。从两名患有先天性缺陷的婴儿、六名患有恶性肿瘤的患者和四名患有遗传性免疫缺陷的患者的尿液中成功分离出BK病毒。
