Lazarević B, Ljubić A, Stević R, Sulović V, Rosić B, Radunović N, Ilić S
Gynecology and Obstetrics Clinic, UKC, Belgrade, Yugoslavi.
Clin Exp Obstet Gynecol. 1991;18(2):85-9.
Fetal blood samples were collected by cordocentesis from 82 pregnant women; 12 of whom had severe forms of Rh isoimmunization, while 70 comprised the control group. The mean hematocrit value in the group under investigation was 15.72 +/- 3.62% and indication of severe anemia. The pH value in this group was 7.31 +/- 0.06; pCO2 partial pressure 6.36 +/- 0.64; O2-2.65 +/- 0.89 kPa; bicarbonate 23.84 +/- 3.02 mMol/l: base excess was -2.72 +/- 2.66 mMol/l and saturation 28.66 +/- 15.56%. In the control group the following values were established: pH -7.386 +/- 0.05; partial pressure pCO2-4.980 +/- 0.31 kPa; O2--4.960 +/- 0.90 kPa; bicarbonate 21.560 +/- 0.27 mMol/l; base excess -2.30 +/- 0.90 mMol/l and saturation 67.23 +/- 11.60%. The pH, partial pressure O2 and saturation values were significantly lower, while partial pressure CO2 was significantly higher in the investigated group than in the control group. Bicarbonates and base excess do not change significantly in the presence of anemia. Fetal blood sampling carried out by means of cordocentesis is the most reliable method for assessment of the degree of fetal anemia. The values of acid base parameters and of blood gases are an indication of either respiratory, respiratory-metabolic or metabolic acidosis. The possibilities of prenatal diagnostics, undoubtedly, contribute to a significant reduction of perinatal mortality.
通过脐静脉穿刺术从82名孕妇中采集胎儿血样；其中12名孕妇患有严重的Rh血型免疫疾病，另外70名组成对照组。研究组的平均血细胞比容值为15.72±3.62%，表明存在严重贫血。该组的pH值为7.31±0.06；二氧化碳分压为6.36±0.64；氧分压为2.65±0.89kPa；碳酸氢盐为23.84±3.02mmol/L；碱剩余为-2.72±2.66mmol/L，饱和度为28.66±15.56%。对照组的各项数值如下：pH值为7.386±0.05；二氧化碳分压为4.980±0.31kPa；氧分压为4.960±0.90kPa；碳酸氢盐为21.560±0.27mmol/L；碱剩余为-2.30±0.90mmol/L，饱和度为67.23±11.60%。研究组的pH值、氧分压和饱和度明显低于对照组，而二氧化碳分压则明显高于对照组。在贫血情况下，碳酸氢盐和碱剩余没有明显变化。通过脐静脉穿刺术进行胎儿血样采集是评估胎儿贫血程度最可靠的方法。酸碱参数和血气值表明存在呼吸性、呼吸代谢性或代谢性酸中毒。毫无疑问，产前诊断的可能性有助于显著降低围产期死亡率。
