Shiokawa S, Shingu M, Nishimura M, Yasuda M, Yamamoto M, Tawara T, Wada T, Nobunaga M
Department of Clinical Immunology, Kyushu University, Beppu, Japan.
Clin Rheumatol. 1991 Jun;10(2):201-5. doi: 10.1007/BF02207665.
A case of multicentric reticulohistiocytosis in a 60-year-old Japanese woman associated with subclinical Sjögren's syndrome is presented. The clinical features along with the light microscopic studies are commented. Partial improvement of the skin lesions and tendon sheath swelling was achieved after treatment with cyclophosphamide but the patient's general condition remained unchanged. Taking the rarity of multicentric reticulohistiocytosis into account, coexistence of these two conditions in the present and previously reported cases suggests that an autoimmune mechanism may play a part in the pathogenesis of multicentric reticulohistiocytosis.
本文报告了一例60岁日本女性的多中心性网状组织细胞增多症，该病例与亚临床干燥综合征相关。文中对其临床特征及光镜检查结果进行了评论。经环磷酰胺治疗后，皮肤病变和腱鞘肿胀部分改善，但患者的总体状况未变。考虑到多中心性网状组织细胞增多症的罕见性，在本病例及既往报道病例中这两种疾病并存提示自身免疫机制可能在多中心性网状组织细胞增多症的发病机制中起作用。
