Liu Yao, Dinkin Marc J, Loewenstein John I, Rizzo Joseph F, Cestari Dean M
Neuro-Ophthalmology Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA.
J Neuroophthalmol. 2008 Dec;28(4):278-82. doi: 10.1097/WNO.0b013e31818e3ece.
Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage. Multifocal electroretinography (mfERG) disclosed markedly low-amplitude responses at fixation and in the regions corresponding to the visual field defects. These results suggested that the visual dysfunction might be entirely attributable to retinal rather than optic nerve toxicity. These are the first reported patients to show mfERG abnormalities that correspond to bitemporal visual field defects and add to the growing evidence that ethambutol damages the retina.
两名因鸟分枝杆菌复合群感染接受乙胺丁醇治疗数月后出现视力下降的患者出现了双颞侧视野缺损，提示视交叉受损。多焦视网膜电图（mfERG）显示在注视点以及与视野缺损相对应的区域有明显低振幅反应。这些结果表明，视觉功能障碍可能完全归因于视网膜毒性而非视神经毒性。这是首次报道的显示mfERG异常与双颞侧视野缺损相对应的患者，进一步证明了乙胺丁醇会损害视网膜。
