岩藻糖苷酶假基因FUCA1P定位于染色体区域2q31----q32。

Assignment of the fucosidase pseudogene FUCA1P to chromosome region 2q31----q32.

作者信息

Coucke P, Mangelschots K, Speleman F, Bossuyt P, Van Oostveldt P, Van der Auwera B, Carritt B, Willems P J

机构信息

Department of Medical Genetics, University of Antwerp-U.I.A., Belgium.

出版信息

Cytogenet Cell Genet. 1991;57(2-3):120-2. doi: 10.1159/000133129.

DOI:10.1159/000133129

PMID:1914520

Abstract

FUCA1P is a pseudogene of the structural fucosidase gene FUCA1. The former has been mapped to human chromosome 2, whereas the latter has been localized to chromosome 1p34----p36. We have further localized FUCA1P to chromosomal band 2q31----q32 by fluorescent in situ hybridization and digital imaging microscopy. This localization was confirmed by linkage analysis between FUCA1P and the COL3A1 gene in 2q24----q32 which gave maximal lod scores of 4.03 at 3% recombination.

摘要

FUCA1P是结构岩藻糖苷酶基因FUCA1的假基因。前者已被定位到人类2号染色体，而后者定位于1p34----p36染色体。我们通过荧光原位杂交和数字成像显微镜进一步将FUCA1P定位到染色体带2q31----q32。通过FUCA1P与2q24----q32区域的COL3A1基因之间的连锁分析证实了这种定位，在3%重组率时获得了最高对数优势分数4.03。