Pinedo Pablo J, Wang Chenguang, Li Yao, Rae D Owen, Wu Rongling
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA.
Mamm Genome. 2009 Feb;20(2):124-9. doi: 10.1007/s00335-008-9167-0. Epub 2009 Jan 15.
Paratuberculosis (Johne's disease), caused by Mycobacterium avium subsp. paratuberculosis, is an important disease for bovines, although its genetic basis is poorly understood. In this study, three candidate genes were typed to study the associations between single nucleotide polymorphisms (SNPs) and paratuberculosis susceptibility (measured in a 1 or 0 form) at the haplotype level. A significant risk haplotype, constructed by a variant allele (C) at the first SNP and a common allele (A) at the second SNP, within the CARD15 gene was detected to trigger genetic effects on paratuberculosis infection in an overdominace manner. Marginally significant haplotypes were identified for the other two genes. The results obtained will provide scientific guidance about the selection and prediction of resistance types in bovines.
副结核病（约翰氏病）由鸟分枝杆菌副结核亚种引起，是牛的一种重要疾病，尽管其遗传基础尚不清楚。在本研究中，对三个候选基因进行分型，以研究单核苷酸多态性（SNP）与单倍型水平上副结核病易感性（以1或0形式衡量）之间的关联。在CARD15基因内，检测到一个由第一个SNP处的变异等位基因（C）和第二个SNP处的常见等位基因（A）构建的显著风险单倍型，以超显性方式引发对副结核病感染的遗传效应。另外两个基因也鉴定出了边缘显著的单倍型。所获得的结果将为牛抗性类型的选择和预测提供科学指导。
