Tang Chunbo, Chen Ning, Wu Mingyue, Yuan Hua, Du Yifei
Dental Research Institute, School of Stomatology, Nanjing Medical University, 136 Hanzhong Rd., Nanjing 210029, China.
Breast Cancer Res Treat. 2009 Sep;117(2):391-9. doi: 10.1007/s10549-008-0262-4. Epub 2009 Jan 6.
Several polymorphisms in the vitamin D receptor (VDR) gene have been reported to influence breast cancer risk. However, the published findings have been conflicting. We conducted a meta-analysis of 21 case-control studies with Fok1 (eight studies with 5,284 cases and 7,500 controls), Bsm1 (14 studies with 5,498 cases and 7,943 controls), Apa1 (four studies with 1,138 cases and 7,943 controls), Taq1 (10 studies with 4,459 cases and 5,485 controls) polymorphisms. The results showed Fok1 polymorphism was associated with an overall significantly increased risk of breast cancer (ff vs. FF: OR = 1.15, 95% CI = 1.03-1.28; the recessive model ff vs. Ff + FF: OR = 1.14, 95% CI = 1.03-1.26). In subgroup analysis, a significant association was evident between Fok1 polymorphism and breast cancer in European population (ff vs. FF: OR = 1.16, 95% CI = 1.04-1.30; the recessive model ff vs. Ff + FF: OR = 1.15, 95% CI = 1.04-1.28). There was no between-study heterogeneity in any of these analyses. No significant associations were observed between the Bsm1, Apa1 and Taq1 variants and breast cancer risk. So, the current meta-analysis shows that Fok1 may be a susceptibility biomarker for breast cancer especially in European population.
据报道，维生素D受体（VDR）基因中的几种多态性会影响乳腺癌风险。然而，已发表的研究结果相互矛盾。我们对21项病例对照研究进行了荟萃分析，这些研究涉及Fok1（8项研究，5284例病例和7500例对照）、Bsm1（14项研究，5498例病例和7943例对照）、Apa1（4项研究，1138例病例和7943例对照）、Taq1（10项研究，4459例病例和5485例对照）多态性。结果显示，Fok1多态性与乳腺癌总体风险显著增加相关（ff与FF相比：OR = 1.15，95%CI = 1.03 - 1.28；隐性模型ff与Ff + FF相比：OR = 1.14，95%CI = 1.03 - 1.26）。在亚组分析中，欧洲人群中Fok1多态性与乳腺癌之间存在显著关联（ff与FF相比：OR = 1.16，95%CI = 1.04 - 1.30；隐性模型ff与Ff + FF相比：OR = 1.15，95%CI = 1.04 - 1.28）。这些分析中均不存在研究间异质性。未观察到Bsm1、Apa1和Taq1变体与乳腺癌风险之间存在显著关联。因此，当前的荟萃分析表明，Fok1可能是乳腺癌的一个易感生物标志物，尤其是在欧洲人群中。
