Vistoso Monreal Anette, Polonsky Gregory, Shiboski Caroline, Sankar Vidya, Villa Alessandro
Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, United States.
General Practice Residency, Department of Oral and Maxillofacial Surgery, University of California, San Francisco, San Francisco, CA, United States.
Front Oral Health. 2022 Jun 9;3:907778. doi: 10.3389/froh.2022.907778. eCollection 2022.
The number of cancer survivors are increasing and so are the oral toxicities from cancer therapy. Most patients receiving treatment for cancer develop some form of oral adverse events including, but not limited to, mucositis, opportunistic infections, dry mouth, and/or osteonecrosis of the jaw. One of the most common complications from head and neck cancer radiation therapy is salivary gland dysfunction (SGD). SGD is an umbrella term that includes the subjective sensation of dry mouth (xerostomia) and hyposalivation (objective reduction of the salivary flow rate). Dry mouth in cancer patients may lead to functional defects (e.g., eating, speaking, and swallowing), increase the risk of dental caries and oral candidiasis, and can have a negative effect on the nutritional and psychological status of the patients. The aim of this mini review was to summarize the current criteria for diagnosis and management of SGD associated with cancer treatment.
癌症幸存者的数量在不断增加，癌症治疗带来的口腔毒性也在增加。大多数接受癌症治疗的患者会出现某种形式的口腔不良事件，包括但不限于粘膜炎、机会性感染、口干和/或颌骨坏死。头颈部癌症放射治疗最常见的并发症之一是唾液腺功能障碍（SGD）。SGD是一个统称，包括口干（口腔干燥症）的主观感觉和唾液分泌减少（唾液流速客观降低）。癌症患者的口干可能导致功能缺陷（如进食、说话和吞咽），增加龋齿和口腔念珠菌病的风险，并可能对患者的营养和心理状况产生负面影响。本小型综述的目的是总结目前与癌症治疗相关的SGD的诊断和管理标准。
