Foitzik T, Klar E, Runkel N, Buhr H J
Chirurgische Universitätsklinik, Heidelberg.
Chirurg. 1991 Jun;62(6):486-92.
116 patients admitted for acute pancreatitis were analysed. In 80% of patients presenting biliary pancreatitis cholecystectomy and bile duct exploration was the prevalent treatment, in 7.8% pancreatic necrosis was removed. Indications to operate on patients with non-biliary pancreatitis included enhancement of pancreatic inflammation revealed by computed tomography and multi-organ-failure or sepsis complicating the course of the disease (incidence of laparotomy 20.3%, incidence of necrosectomy 12.3%). According to this concept 2 out of 3 patients presenting partial pancreatic necrosis recovered without operation. Lethality of patients with acute necrotizing pancreatitis (6.9%) was accounted 25%, over-all mortality 6%. Methods used for classification of severity of acute pancreatitis (Mainz classification, Ranson criteria) turned out to be not reliable. Clinical staging of pancreatitis was not in accordance with intraoperative findings in 51.9% of cases. As a prerequisite for stage-dependent therapy new objective data to access severity and clinical course of acute pancreatitis have to be worked out.
对116例因急性胰腺炎入院的患者进行了分析。在出现胆源性胰腺炎的患者中,80%的患者接受了胆囊切除术和胆管探查术,7.8%的患者进行了胰腺坏死组织清除术。非胆源性胰腺炎患者的手术指征包括计算机断层扫描显示的胰腺炎症加重以及疾病过程中出现多器官功能衰竭或脓毒症(剖腹手术发生率为20.3%,坏死组织清除术发生率为12.3%)。根据这一概念,三分之二出现部分胰腺坏死的患者未经手术即康复。急性坏死性胰腺炎患者的死亡率为6.9%,占总死亡率的25%,总体死亡率为6%。结果表明,用于急性胰腺炎严重程度分类的方法(美因茨分类法、兰森标准)并不可靠。在51.9%的病例中,胰腺炎的临床分期与术中发现不符。作为分期依赖性治疗的前提条件,必须找出评估急性胰腺炎严重程度和临床过程的新的客观数据。