Wang N P
Department of Infectious Diseases, Nangfang Hospital, Guangzhou.
Zhonghua Yu Fang Yi Xue Za Zhi. 1991 May;25(3):161-3.
A total of 107 subjects in population without HBsAg, anti-HBs and anti-HBc were inoculated with hepatitis B vaccine in month 0, 1, 6, respectively and followed up for three years. Seven months after the administration of first dose of vaccine response rate of anti-HBs was 94.4%, of which 68.2% had a S/N ratio greater than 10. Three years later the response rate of anti-HBs dropped to 75.7% and the rate of S/N ratio 10 fell to 46.7%, 20 subjects turned negative for anti-HBs and one turned positive for HBsAg. During the same period, of 124 adults who were hepatitis B virus markers negative and were not inoculated, 14 became HBsAg-positive (ALT increased in 3 of them) and 3 turned anti-HBs positive.
共有107名无乙肝表面抗原（HBsAg）、乙肝表面抗体（抗-HBs）和乙肝核心抗体（抗-HBc）的人群分别在第0、1、6个月接种了乙肝疫苗，并进行了三年的随访。首剂疫苗接种七个月后，抗-HBs的应答率为94.4%，其中68.2%的S/N比值大于10。三年后，抗-HBs的应答率降至75.7%，S/N比值≥10的比例降至46.7%，20名受试者抗-HBs转阴，1名受试者HBsAg转阳。同期，124名乙肝病毒标志物阴性且未接种疫苗的成年人中，14人HBsAg转阳（其中3人谷丙转氨酶升高），3人抗-HBs转阳。
