[Preliminary evaluation of inoculation of hepatitis B vaccine in normal adult subjects].

A total of 107 subjects in population without HBsAg, anti-HBs and anti-HBc were inoculated with hepatitis B vaccine in month 0, 1, 6, respectively and followed up for three years. Seven months after the administration of first dose of vaccine response rate of anti-HBs was 94.4%, of which 68.2% had a S/N ratio greater than 10. Three years later the response rate of anti-HBs dropped to 75.7% and the rate of S/N ratio 10 fell to 46.7%, 20 subjects turned negative for anti-HBs and one turned positive for HBsAg. During the same period, of 124 adults who were hepatitis B virus markers negative and were not inoculated, 14 became HBsAg-positive (ALT increased in 3 of them) and 3 turned anti-HBs positive.