Liu K Z
Zhonghua Yu Fang Yi Xue Za Zhi. 1989 May;23(3):132-4.
After hepatitis B vaccine immunization, serum antibody response was of primary type in 33 cases with anti-HBs less than 2.1 S/N (S/N Ratio Unit) at T0, the anti-HBs positive rate was 39.4%, 84.8%, 96.7% and 96.7% in T1, T2, T0 and T12 respectively. Anti-HBs S/N rose gradually month by month, the antibody response in younger children was better than that in adult. Anamnestic type in 38 cases with anti-HBs greater than 2.1 S/N at T0, the antibody levels rose rapidly in T1, T2 and began to fall in T8. The children were negative for HBsAg, anti-HBs and anti-HBc in sera by RPHA, PHA and ELISA respectively, most (100% in 1-4 age group and 63.2% in 5-9 age group) of them were also negative for HBV serological markers by SPRIA repeatedly, thus they were susceptible and need for hepatitis B vaccine immunization. Indication of hepatitis B vaccination for adult population was also discussed.
乙肝疫苗免疫后，T0时抗-HBs小于2.1 S/N（S/N比值单位）的33例血清抗体反应为初免型，T1、T2、T0和T12时抗-HBs阳性率分别为39.4%、84.8%、96.7%和96.7%。抗-HBs S/N逐月逐渐升高，幼儿的抗体反应优于成人。T0时抗-HBs大于2.1 S/N的38例为回忆型，T1、T2时抗体水平迅速升高，T8时开始下降。通过反向被动血凝试验（RPHA）、PHA和酶联免疫吸附测定（ELISA）分别检测，儿童血清中HBsAg、抗-HBs和抗-HBc均为阴性，其中大多数（1-4岁年龄组为100%，5-9岁年龄组为63.2%）通过固相放射免疫分析（SPRIA）反复检测乙肝血清学标志物也为阴性，因此他们易感，需要接种乙肝疫苗。还讨论了成人乙肝疫苗接种的指征。
