甲基丙烯酸化壳聚糖/聚N-异丙基丙烯酰胺杂化双敏水凝胶的光聚合作用作为药物递送载体
Photopolymerization of methacrylated chitosan/PNIPAAm hybrid dual-sensitive hydrogels as carrier for drug delivery.
作者信息
Han Jing, Wang Kemin, Yang Dongzhi, Nie Jun
机构信息
Beijing University of Chemical Technology, PR China.
出版信息
Int J Biol Macromol. 2009 Apr 1;44(3):229-35. doi: 10.1016/j.ijbiomac.2008.12.009. Epub 2008 Dec 25.
A series of hybrid hydrogels based on glycidyl methacrylated chitosan (CS-GMA) and N-isopropylacrylamide (NIPAAm) were designed and prepared via photopolymerization technology. The hydrogels were characterized by Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC) and optical transmittance. The interior morphology of hydrogels was investigated by scanning electron microscopy (SEM). The swelling experiment results revealed that hybrid hydrogel exhibited combined pH and temperature sensitivities. Acid orange 8 (AO8) and 5-flurouracil (5-Fu) were selected as model drugs for examining their release from hydrogels. The results suggested that hydrogel composition and pH value of buffer solution had great influences on release profiles.
通过光聚合技术设计并制备了一系列基于甲基丙烯酸缩水甘油酯壳聚糖（CS-GMA）和N-异丙基丙烯酰胺（NIPAAm）的杂化水凝胶。通过傅里叶变换红外光谱（FT-IR）、差示扫描量热法（DSC）和透光率对水凝胶进行了表征。通过扫描电子显微镜（SEM）研究了水凝胶的内部形态。溶胀实验结果表明，杂化水凝胶表现出pH和温度双重敏感性。选择酸性橙8（AO8）和5-氟尿嘧啶（5-Fu）作为模型药物，考察它们从水凝胶中的释放情况。结果表明，水凝胶组成和缓冲溶液的pH值对释放曲线有很大影响。
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