Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.
The Affiliated Hospital of Qingdao University, Qingdao 266071, China.
Molecules. 2023 Sep 24;28(19):6788. doi: 10.3390/molecules28196788.
The wounds caused by war, accidents, and diseases require timely and effective treatment. Polysaccharides, as natural macromolecules, have good biocompatibility and unique functions, and are excellent substrates for constructing new wound dressings. Short-chain chitosan (SCS) has good water solubility and, importantly, retains a large number of active amino groups. We first introduce double bonds to SCS. This chitosan derivative can be entangled with sodium alginate (SA) through electrostatic interaction. The flowing sol can be applied to a wound with an irregular shape. Under the initiation of a photoinitiator, the internal double bonds are broken and cross-linked to form a gel. The prepared hydrogel wound dressing exhibited good antibacterial properties and can provide a microenvironment conducive to wound repair. A polydeoxyribonucleotide (PDRN) has been proven to have encouraging therapeutic effects for wound healing. PDRN can be condensed by branched polyethylenimine (PEI) to form a nucleic acid delivery system, which can be efficiently uptaken by cells. The cooperation of hydrogel and nucleic-acid-based therapy presented good results in a mouse full-thickness skin wound model.
战争、事故和疾病造成的创伤需要及时有效的治疗。多糖作为天然大分子，具有良好的生物相容性和独特的功能，是构建新型创伤敷料的优秀基质。短链壳聚糖（SCS）具有良好的水溶性，重要的是保留了大量的活性氨基。我们首先向 SCS 中引入双键。这种壳聚糖衍生物可以通过静电相互作用与海藻酸钠（SA）缠结。流动的溶胶可应用于形状不规则的伤口。在光引发剂的引发下，内部双键断裂并交联形成凝胶。所制备的水凝胶创伤敷料表现出良好的抗菌性能，并能提供有利于伤口修复的微环境。多脱氧核糖核苷酸（PDRN）已被证明对伤口愈合具有令人鼓舞的治疗效果。PDRN 可以通过支化聚乙烯亚胺（PEI）缩合形成核酸递药系统，该系统可以被细胞高效摄取。水凝胶和基于核酸的治疗的协同作用在小鼠全层皮肤创伤模型中取得了良好的效果。
