Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.
Carbohydr Res. 2010 Feb 26;345(4):462-8. doi: 10.1016/j.carres.2009.11.029. Epub 2009 Dec 4.
A novel pH-responsive hydrogel (CHC) composed of N-carboxyethyl chitosan (CEC) and N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride (HTCC) was synthesized by the redox polymerization technique. Turbidimetric titrations were used to determine the stoichiometric ratio of these two chitosan derivatives. The hydrogel was characterized by FT-IR, thermal gravimetric analysis (TGA), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). The dynamic transport of water showed that the hydrogel reached equilibrium within 48h. The swelling ratio of CHC hydrogel depended significantly on the pH of the buffer solution. The performance of the CHC as a matrix for the controlled release of BSA was investigated. It was found that the release behavior was determined by pH value of the medium as well as the intermolecular interaction between BSA and the hydrogels.
一种新型的 pH 响应水凝胶（CHC）由 N-羧乙基壳聚糖（CEC）和 N-[(2-羟基-3-三甲基铵)丙基]壳聚糖氯化物（HTCC）组成，通过氧化还原聚合技术合成。比浊滴定法用于确定这两种壳聚糖衍生物的化学计量比。水凝胶的结构特征通过傅里叶变换红外光谱（FT-IR）、热重分析（TGA）、X 射线衍射（XRD）和扫描电子显微镜（SEM）进行了研究。动态水传输表明，水凝胶在 48 小时内达到平衡。CHC 水凝胶的溶胀比显著依赖于缓冲溶液的 pH 值。研究了 CHC 作为 BSA 控制释放基质的性能。结果发现，释放行为不仅取决于介质的 pH 值，还取决于 BSA 与水凝胶之间的分子间相互作用。
