Chemin I, Zoulim F
INSERM, U871, 69003 Lyon, France.
Cancer Lett. 2009 Dec 1;286(1):52-9. doi: 10.1016/j.canlet.2008.12.003. Epub 2009 Jan 14.
A number of risk factors appear to play a role in Hepatocellularcinoma (HCC), HBV infection being one of the most important. Chronic inflammation and cytokines are key determinants in the development of fibrosis and liver cell proliferation. HBV DNA integration and/or expression of HBV proteins may have a direct effect on cellular functions. Occult hepatitis B virus infection is characterized by persistence of HBV DNA in hepatitis B surface antigen-negative individuals. There are evidences that occult HBV is a risk factor for the development of HCC and that the potential mechanisms whereby overt HBV might induce tumour formation are mostly maintained.
多种风险因素似乎在肝细胞癌（HCC）中发挥作用，其中乙肝病毒（HBV）感染是最重要的因素之一。慢性炎症和细胞因子是纤维化和肝细胞增殖发展的关键决定因素。HBV DNA整合和/或HBV蛋白表达可能对细胞功能产生直接影响。隐匿性乙肝病毒感染的特征是在乙肝表面抗原阴性个体中持续存在HBV DNA。有证据表明，隐匿性HBV是HCC发生的一个风险因素，并且显性HBV可能诱导肿瘤形成的潜在机制大多得以保留。
