Park Eun-Sook, Dezhbord Mehrangiz, Lee Ah Ram, Park Bo Bae, Kim Kyun-Hwan
Institute of Biomedical Science and Technology, School of Medicine, Konkuk University, Seoul 05029, Korea.
Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon 16419, Korea.
Cancers (Basel). 2022 Jul 22;14(15):3566. doi: 10.3390/cancers14153566.
The liver is unique in its ability to regenerate in response to damage. The complex process of liver regeneration consists of multiple interactive pathways. About 2 billion people worldwide have been infected with hepatitis B virus (HBV), and HBV causes 686,000 deaths each year due to its complications. Long-term infection with HBV, which causes chronic inflammation, leads to serious liver-related diseases, including cirrhosis and hepatocellular carcinoma. HBV infection has been reported to interfere with the critical mechanisms required for liver regeneration. In this review, the studies on liver tissue characteristics and liver regeneration mechanisms are summarized. Moreover, the inhibitory mechanisms of HBV infection in liver regeneration are investigated. Finally, the association between interrupted liver regeneration and hepatocarcinogenesis, which are both triggered by HBV infection, is outlined. Understanding the fundamental and complex liver regeneration process is expected to provide significant therapeutic advantages for HBV-associated hepatocellular carcinoma.
肝脏在响应损伤时的再生能力是独一无二的。肝脏再生的复杂过程由多个相互作用的途径组成。全球约有20亿人感染了乙型肝炎病毒（HBV），HBV每年因其并发症导致68.6万人死亡。长期感染HBV会引起慢性炎症，进而导致严重的肝脏相关疾病，包括肝硬化和肝细胞癌。据报道，HBV感染会干扰肝脏再生所需的关键机制。在本综述中，总结了关于肝脏组织特征和肝脏再生机制的研究。此外，还研究了HBV感染在肝脏再生中的抑制机制。最后，概述了由HBV感染引发的肝脏再生中断与肝癌发生之间的关联。了解肝脏再生这一基本而复杂的过程有望为HBV相关的肝细胞癌提供显著的治疗优势。
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