Glass D B, Gerrard J M, Townsend D, Carr D W, White J G, Goldberg N D
J Cyclic Nucleotide Res. 1977 Feb;3(1):37-44.
Arachidonic acid- or collagen-induced aggregation was accompanied by a progressive elevation in the level of cyclic GMP in washed human platelets with no significant alteration in the concentration of cyclic AMP. The extent of the increase in cyclic GMP was proportional to the concentration of arachidonic acid added. Enhanced accumulation of cyclic GMP produced by arachidonic or collagen was prevented by prior exposure of platelets to aspirin or indomethacin. Prostaglandin endoperoxide G2 caused platelet aggregation and an increase in cyclic GMP concentration; neither event was blocked by prostaglandin synthesis inhibitors. These results indicate that the generation of prostaglandin endoperoxides is a step in the sequence of events in platelet aggregation leading to the enhanced accumulation of cyclic GMP.
花生四烯酸或胶原诱导的聚集伴随着洗涤后的人血小板中环鸟苷酸（cGMP）水平的逐渐升高，而环磷酸腺苷（cAMP）浓度无明显变化。cGMP增加的程度与添加的花生四烯酸浓度成正比。血小板预先暴露于阿司匹林或吲哚美辛可阻止花生四烯酸或胶原引起的cGMP增强积累。前列腺素内过氧化物G2引起血小板聚集并使cGMP浓度增加；这两个事件均未被前列腺素合成抑制剂阻断。这些结果表明，前列腺素内过氧化物的生成是血小板聚集中导致cGMP增强积累的一系列事件中的一个步骤。
