Kliem V, Maschek H, Bleck J, Schmidt F W
Abteilung Nephrologie, Medizinische Hochschule Hannover.
Dtsch Med Wochenschr. 1991 Sep 27;116(39):1468-72. doi: 10.1055/s-2008-1063774.
A 43-year-old alcohol-dependent man had sustained three acute episodes of chronic pancreatitis. At the third hospital admission enlarged axillary and supraclavicular lymph nodes, widening of the mediastinum and bone metastases were noted. Cytological examination of a needle biopsy of the supraclavicular lymph node revealed a poorly differentiated adenocarcinoma. Because of the marked enlargement of the pancreas and the history, a rapidly and unusually metastasizing carcinoma of the pancreas was diagnosed. In view of the rapid deterioration of the patient no chemotherapy was begun and he died 4 weeks after admission. Autopsy confirmed the chronic pancreatitis but no carcinoma of the pancreas. Instead there was a peritoneal mesothelioma with extensive lymphogenous and haematogenous metastases. The incidence of this tumour is ever increasing. It should be included in the differential diagnosis, because survival time can be increased if the correct diagnosis is made very early.
一名43岁的酒精依赖男性曾经历过三次慢性胰腺炎急性发作。第三次入院时,发现腋窝和锁骨上淋巴结肿大、纵隔增宽以及骨转移。锁骨上淋巴结针吸活检的细胞学检查显示为低分化腺癌。鉴于胰腺明显肿大及病史,诊断为快速且异常转移的胰腺癌。鉴于患者病情迅速恶化,未开始化疗,入院4周后死亡。尸检证实存在慢性胰腺炎,但未发现胰腺癌。相反,发现了伴有广泛淋巴道和血行转移的腹膜间皮瘤。这种肿瘤的发病率在不断上升。应将其纳入鉴别诊断,因为如果能极早期做出正确诊断,生存时间可以延长。