Thompson D H, Khan A, Gonzalez C, Auclair P
Department of Otolaryngology and Oral Pathology, National Naval Medical Center, Bethesda, MD.
Ear Nose Throat J. 1991 Jul;70(7):462-8.
AF is a non-encapsulated, non-metastasizing fibrous tumor that has a tendency for local recurrence in up to 70% of cases. We suspect possible genetic disposition. Microscopically, AF is a poorly circumscribed fibrous tumor that infiltrates surrounding tissues. It presents as a painless, rapidly growing mass with a predilection for bone destruction. Treatment consists of a carefully planned en bloc resection after biopsy and accurate radiologic evaluation of the extent of the tumor. Radiation therapy and chemotherapy can be used as adjuvant therapy in selected patients. Three patients with AF of the head and neck are described, of which two were found to have congenital disorders of mesodermal development.
非骨化性纤维瘤是一种无包膜、不发生转移的纤维性肿瘤，高达70%的病例有局部复发倾向。我们怀疑可能存在遗传易感性。在显微镜下，非骨化性纤维瘤是一种边界不清的纤维性肿瘤，可浸润周围组织。它表现为无痛性、生长迅速的肿块，易导致骨质破坏。治疗包括活检后精心规划的整块切除以及对肿瘤范围进行精确的放射学评估。放疗和化疗可用于特定患者的辅助治疗。本文描述了3例头颈部非骨化性纤维瘤患者，其中2例被发现患有中胚层发育的先天性疾病。
