Righetti Marco
Nephrology & Dialysis Unit, Vimercate Hospital, Vimercate, Italy.
Recent Pat Cardiovasc Drug Discov. 2009 Jan;4(1):37-44. doi: 10.2174/157489009787260061.
Vitamin B deficiency causes many diseases, which may be improved by vitamin B supplementation. Homocysteine, a sulphur amino acid, is frequently increased in patients with vitamin B deficiency, chronic renal failure and metabolism disorders. Bone and cardiovascular disease is often detected in patients with renal disease or homocystinuria. This review shows the most important discoveries, including recent patents, about vitamin B therapy not only in hyperhomocysteinemic patients but also in the general population. Vitamin B supplementation may be useful to reduce bone and cardiovascular events, but until now prospective intervention studies have given uncertain results. We need well-done randomized controlled trials to verify the effects of vitamin B treatment on these hard end-points.
维生素B缺乏会引发多种疾病，补充维生素B可能会改善这些疾病。同型半胱氨酸是一种含硫氨基酸，在维生素B缺乏、慢性肾衰竭和代谢紊乱患者中常常升高。肾病或同型胱氨酸尿症患者常被检测出患有骨骼和心血管疾病。这篇综述展示了关于维生素B疗法的最重要发现，包括近期专利，不仅涉及高同型半胱氨酸血症患者，也涉及普通人群。补充维生素B可能有助于减少骨骼和心血管事件，但到目前为止，前瞻性干预研究给出的结果并不确定。我们需要开展完善的随机对照试验来验证维生素B治疗对这些硬性终点的影响。
