疟疾病原体免疫复合物何时不再是免疫复合物？
When is a malaria immune complex not an immune complex?
作者信息
Pleass R J
机构信息
Institute of Genetics, Queen's Medical Centre, Nottingham, UK.
出版信息
Parasite Immunol. 2009 Feb;31(2):61-3. doi: 10.1111/j.1365-3024.2008.01076.x.
Abstract
Immune complexes (ICs) are believed to play an important role in malaria pathology, and an interesting article by Mibei et al. recently published by Parasite Immunology suggests that IgG4 and IgE are particularly important. However, researchers should be aware of potential pitfalls to current assays aimed at measuring plasma ICs and correlating these to deposition in tissues.
摘要
免疫复合物（ICs）被认为在疟疾病理学中起重要作用，《寄生虫免疫学》最近发表的一篇由米贝等人撰写的有趣文章表明，IgG4和IgE尤为重要。然而，研究人员应意识到当前旨在测量血浆ICs并将其与组织沉积相关联的检测方法存在的潜在缺陷。
相似文献
1
When is a malaria immune complex not an immune complex?疟疾病原体免疫复合物何时不再是免疫复合物？
Parasite Immunol. 2009 Feb;31(2):61-3. doi: 10.1111/j.1365-3024.2008.01076.x.
2
Distinct pattern of class and subclass antibodies in immune complexes of children with cerebral malaria and severe malarial anaemia.脑型疟和严重疟疾贫血患儿免疫复合物中不同类型和亚类抗体的模式。
Parasite Immunol. 2008 Jun-Jul;30(6-7):334-41. doi: 10.1111/j.1365-3024.2008.01030.x. Epub 2008 May 6.
3
Causes of reduced immune complex clearance in cerebral malaria.
Parasite Immunol. 2009 Feb;31(2):59; author reply 60. doi: 10.1111/j.1365-3024.2008.01074.x.
4
Immune complex levels in children with severe Plasmodium falciparum malaria.患有严重恶性疟原虫疟疾儿童的免疫复合物水平
Am J Trop Med Hyg. 2005 May;72(5):593-9.
5
Immunoglobulin E, a pathogenic factor in Plasmodium falciparum malaria.免疫球蛋白E，恶性疟原虫疟疾的一个致病因素。
Infect Immun. 1997 Jan;65(1):116-21. doi: 10.1128/iai.65.1.116-121.1997.
6
Differential regulation of IgG subclasses and IgE antimalarial antibody responses in complicated and uncomplicated Plasmodium falciparum malaria.恶性疟原虫复杂型和非复杂型疟疾中IgG亚类及IgE抗疟抗体反应的差异调节
Parasite Immunol. 2007 Sep;29(9):475-83. doi: 10.1111/j.1365-3024.2007.00965.x.
7
IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: association of high IgE levels with cerebral malaria.恶性疟原虫疟疾中的IgE升高及抗疟疾IgE抗体：高IgE水平与脑型疟疾的关联
Clin Exp Immunol. 1994 Aug;97(2):284-92. doi: 10.1111/j.1365-2249.1994.tb06082.x.
8
Total and functional parasite specific IgE responses in Plasmodium falciparum-infected patients exhibiting different clinical status.表现出不同临床状态的恶性疟原虫感染患者的总寄生虫特异性IgE反应和功能性寄生虫特异性IgE反应。
Malar J. 2007 Jan 4;6:1. doi: 10.1186/1475-2875-6-1.
9
Cerebral malaria is associated with IgG2 and IgG4 antibody responses to recombinant Plasmodium falciparum RIFIN antigen.脑型疟疾与针对重组恶性疟原虫RIFIN抗原的IgG2和IgG4抗体反应有关。
Microbes Infect. 2006 Apr;8(5):1269-76. doi: 10.1016/j.micinf.2005.12.007. Epub 2006 Feb 6.
10
Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunity.恶性疟原虫变异表面抗原的表达在导致严重和非严重疟疾的分离株之间存在差异，并会因获得性免疫而发生改变。
J Immunol. 2002 Apr 1;168(7):3444-50. doi: 10.4049/jimmunol.168.7.3444.
引用本文的文献
1
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccine.R21/基质-M疟疾疫苗诱导的血清学抗体的库、功能和结构
J Exp Med. 2025 Oct 6;222(10). doi: 10.1084/jem.20241908. Epub 2025 Jul 28.
2
Malaria inhibits surface expression of complement receptor 1 in monocytes/macrophages, causing decreased immune complex internalization.疟疾抑制单核细胞/巨噬细胞表面补体受体 1 的表达，导致免疫复合物内化减少。
J Immunol. 2013 Apr 1;190(7):3363-72. doi: 10.4049/jimmunol.1103812. Epub 2013 Feb 25.
3
Antibody-dependent transplacental transfer of malaria blood-stage antigen using a human ex vivo placental perfusion model.利用人体胎盘体外灌流模型进行依赖抗体的疟疾血期抗原经胎盘转移。
PLoS One. 2009 Nov 24;4(11):e7986. doi: 10.1371/journal.pone.0007986.
4
Fc-receptors and immunity to malaria: from models to vaccines.Fc受体与疟疾免疫：从模型到疫苗
Parasite Immunol. 2009 Sep;31(9):529-38. doi: 10.1111/j.1365-3024.2009.01101.x.
本文引用的文献
1
Fc-receptors and immunity to malaria: from models to vaccines.Fc受体与疟疾免疫：从模型到疫苗
Parasite Immunol. 2009 Sep;31(9):529-38. doi: 10.1111/j.1365-3024.2009.01101.x.
2
Distinct pattern of class and subclass antibodies in immune complexes of children with cerebral malaria and severe malarial anaemia.脑型疟和严重疟疾贫血患儿免疫复合物中不同类型和亚类抗体的模式。
Parasite Immunol. 2008 Jun-Jul;30(6-7):334-41. doi: 10.1111/j.1365-3024.2008.01030.x. Epub 2008 May 6.
3
Targeting immune complex-mediated hypersensitivity with recombinant soluble human FcgammaRIA (CD64A).
J Immunol. 2008 Jan 1;180(1):580-9. doi: 10.4049/jimmunol.180.1.580.
4
Fcgamma receptors as regulators of immune responses.作为免疫反应调节因子的Fcγ受体
Nat Rev Immunol. 2008 Jan;8(1):34-47. doi: 10.1038/nri2206.
5
Extravasations and emigration of neutrophils to the inflammatory site depend on the interaction of immune-complex with Fcgamma receptors and can be effectively blocked by decoy Fcgamma receptors.中性粒细胞向炎症部位的外渗和移出取决于免疫复合物与Fcγ受体的相互作用，并且可被诱饵Fcγ受体有效阻断。
Blood. 2008 Jan 15;111(2):894-904. doi: 10.1182/blood-2007-04-085944. Epub 2007 Oct 25.
6
Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange.通过动态Fab臂交换实现人IgG4抗体的抗炎活性
Science. 2007 Sep 14;317(5844):1554-7. doi: 10.1126/science.1144603.
7
The importance of human FcgammaRI in mediating protection to malaria.人类Fcγ受体I在介导疟疾保护中的重要性。
PLoS Pathog. 2007 May 18;3(5):e72. doi: 10.1371/journal.ppat.0030072.
8
Total and functional parasite specific IgE responses in Plasmodium falciparum-infected patients exhibiting different clinical status.表现出不同临床状态的恶性疟原虫感染患者的总寄生虫特异性IgE反应和功能性寄生虫特异性IgE反应。
Malar J. 2007 Jan 4;6:1. doi: 10.1186/1475-2875-6-1.
9
Cerebral malaria is associated with IgG2 and IgG4 antibody responses to recombinant Plasmodium falciparum RIFIN antigen.脑型疟疾与针对重组恶性疟原虫RIFIN抗原的IgG2和IgG4抗体反应有关。
Microbes Infect. 2006 Apr;8(5):1269-76. doi: 10.1016/j.micinf.2005.12.007. Epub 2006 Feb 6.
10
Different antibody- and cytokine-mediated responses to Plasmodium falciparum parasite in two sympatric ethnic tribes living in Mali.生活在马里的两个同域民族部落对恶性疟原虫寄生虫的不同抗体和细胞因子介导反应。
Microbes Infect. 2005 Jan;7(1):110-7. doi: 10.1016/j.micinf.2004.09.012. Epub 2004 Dec 16.
Zotero 插件