Greenough A, Hird M F, Gamsu H R
Department of Child Health, King's College Hospital, London, U.K.
Early Hum Dev. 1991 Jul;26(1):29-35. doi: 10.1016/0378-3782(91)90040-a.
In a 12-month period 28 of 164 consecutive very low birthweight (VLBW) infants receiving intensive care within 48 h of birth at King's College Hospital developed chronic lung disease, (oxygen dependence beyond 28 days of age). Fifteen of the 28 infants were eligible for home oxygen therapy, but this was only practical, because of home circumstances, in 8 infants (4.9%). These 8 infants received home oxygen therapy. One further infant, born at term and suffering from pulmonary hypoplasia was also discharged home on oxygen therapy. Two infants subsequently required readmission due to a deterioration in their respiratory status and died. Three others required re-admissions (total duration 32 days) for respiratory problems. The median duration of home oxygen therapy was 17 weeks (range 4-486 days). We conclude that home oxygen therapy is needed by only a very small number of preterm infants and is appropriate for only a proportion of them. Parents need to be counselled carefully regarding the possibility that the need for oxygen might be protracted.
在12个月期间，伦敦国王学院医院出生后48小时内接受重症监护的164例连续超低出生体重（VLBW）婴儿中，有28例患慢性肺病（28日龄后仍依赖氧气）。这28例婴儿中有15例符合家庭氧疗条件，但由于家庭情况，只有8例（4.9%）能够实际接受家庭氧疗。这8例婴儿接受了家庭氧疗。另有1例足月儿因肺发育不全也在出院时接受家庭氧疗。2例婴儿随后因呼吸状况恶化再次入院并死亡。另有3例因呼吸问题再次入院（总时长32天）。家庭氧疗的中位时长为17周（范围4 - 486天）。我们得出结论，只有极少数早产儿需要家庭氧疗，且仅一部分早产儿适合。需要就氧气需求可能持续很长时间的可能性对家长进行仔细的咨询。
