酒精使用障碍患者中抑郁与物质使用的荟萃分析。
Meta-analysis of depression and substance use among individuals with alcohol use disorders.
作者信息
Conner Kenneth R, Pinquart Martin, Gamble Stephanie A
机构信息
Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA.
出版信息
J Subst Abuse Treat. 2009 Sep;37(2):127-37. doi: 10.1016/j.jsat.2008.11.007. Epub 2009 Jan 15.
The relationships of depression with alcohol and drug use and impairment were examined. Additional analyses were conducted to examine moderators of these associations. Empirical reports on adults with alcohol abuse or dependence published in English in peer-reviewed journals since 1986 that contained data on depression and substance use variable(s) were obtained using a systematic search. The search yielded 74 studies including 58 reports from clinical venues, 10 that were community based, and 6 with subjects from both settings. As hypothesized, the analyses showed that depression is associated with concurrent alcohol use and impairment and drug use and impairment. Effect sizes were small. Depression was also related to future alcohol use and impairment, an earlier age of onset of an alcohol use disorder, and higher treatment participation. Age moderated the association between depression and alcohol use and impairment such that the association was stronger in older samples.
研究了抑郁症与酒精和药物使用及损害之间的关系。还进行了额外的分析以检验这些关联的调节因素。通过系统检索，获取了自1986年以来在同行评审期刊上发表的关于酒精滥用或依赖成年人的英文实证报告，这些报告包含抑郁症和物质使用变量的数据。检索得到74项研究，其中58份来自临床场所的报告，10份基于社区，6份的受试者来自这两种场所。如假设的那样，分析表明抑郁症与同时期的酒精使用及损害以及药物使用及损害相关。效应量较小。抑郁症还与未来的酒精使用及损害、酒精使用障碍的更早发病年龄以及更高的治疗参与度有关。年龄调节了抑郁症与酒精使用及损害之间的关联，使得在年龄较大的样本中这种关联更强。
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