Govic Antonina, Levay Elizabeth A, Kent Stephen, Paolini Antonio G
School of Psychological Science, La Trobe University, Bundoora, VIC 3086, Australia.
Physiol Behav. 2009 Mar 23;96(4-5):581-5. doi: 10.1016/j.physbeh.2008.12.012. Epub 2008 Dec 31.
The behavioral outcomes of a calorie restricted diet are often neglected in favour of a more physiological examination of the consequences of calorie restriction (CR). This is especially the case with social behavior. A few findings within the maternal CR literature suggest that adult male social behavior is altered by this regimen. Despite the paucity of findings within the maternal CR literature, a systematic investigation of the behavioral phenotype of males administered an adult-onset CR is completely lacking and was the focus of the current study. Adult male hooded Wistar rats were administered a three week CR, with one group receiving a 25% CR and another group receiving a 50% CR before male-to-male social behavior was examined and compared with ad libitium fed males. Various behavioral elements were modulated by CR, both the CR25% and 50% group initiated contact sooner and engaged in greater social activity compared to the ad libitum fed controls. The CR25% group also demonstrated less non-social (self-grooming) behavior and a greater frequency of walkovers compared to all groups, indicating a propensity towards dominance. The CR50% group demonstrated greater environmental assessment/exploration, as measured by the frequency of rearing. As with the maternal CR literature, an adult-onset chronic CR induces a more socially active behavioral phenotype and reduces interest in non-social behavior in the moderately CR group. Taken together, the social behavioral phenotype can be modulated by a CR initiated and maintained during adulthood.
热量限制饮食的行为结果常常被忽视，人们更倾向于对热量限制（CR）后果进行更生理层面的研究。社会行为方面尤其如此。母体热量限制文献中的一些研究结果表明，这种饮食方案会改变成年雄性的社会行为。尽管母体热量限制文献中的研究结果较少，但目前完全缺乏对成年期开始进行热量限制的雄性行为表型的系统研究，而这正是本研究的重点。对成年雄性带帽Wistar大鼠进行为期三周的热量限制，一组接受25%的热量限制，另一组接受50%的热量限制，然后检查雄性之间的社会行为，并与自由进食的雄性大鼠进行比较。热量限制调节了各种行为要素，与自由进食的对照组相比，25%热量限制组和50%热量限制组都更早开始接触并参与了更多的社会活动。与所有组相比，25%热量限制组还表现出较少的非社会行为（自我梳理）和更高频率的跨越行为，表明其具有支配倾向。通过直立频率衡量，50%热量限制组表现出更多的环境评估/探索行为。与母体热量限制文献一样，成年期开始的慢性热量限制会诱导出更具社交活跃度的行为表型，并降低中度热量限制组对非社会行为的兴趣。综上所述，成年期开始并维持的热量限制可以调节社会行为表型。
