Govic Antonina, Kent Stephen, Levay Elizabeth A, Hazi Agnes, Penman Jim, Paolini Antonio G
School of Psychological Science, La Trobe University, Bundoora, VIC 3086, Australia.
Physiol Behav. 2008 Jun 9;94(3):516-22. doi: 10.1016/j.physbeh.2008.03.007. Epub 2008 Mar 20.
Calorie restriction (CR) during sensitive perinatal periods has consistently been demonstrated to alter the development of a variety of physiological systems, which consequently affect behavior. This study compared the social behavior and sexual behavior of the adult male offspring of mothers administered a 25% CR at one of four times in the perinatal period: a brief period preconception, during gestation, during lactation, or a lifelong restriction (beginning at conception and continuing throughout life). Levels of serum testosterone were also determined in these animals. Social interaction increased in the gestation and lifelong CR groups. The lifelong group also exhibited more dominant type behaviors. CR during preconception and lactation resulted in offspring that displayed an enhanced and more efficient copulatory pattern compared to all other conditions. This was demonstrated by a reduced frequency of intromissions, shorter latency to ejaculation, and a greater frequency of ejaculations by the preconception and lactation group compared to some, if not all of the other CR groups and controls. Serum testosterone was significantly higher in the preconception group compared to controls. These findings indicate that CR during specific periods of development can differentially alter the social behavioral phenotype and hormone levels in adulthood.
在敏感的围产期进行热量限制（CR）已被反复证明会改变多种生理系统的发育，进而影响行为。本研究比较了在围产期四个时间段之一接受25%热量限制的母亲所生成年雄性后代的社会行为和性行为，这四个时间段分别为：受孕前的短暂时期、妊娠期、哺乳期或终身限制（从受孕开始并持续一生）。还测定了这些动物的血清睾酮水平。妊娠期和终身热量限制组的社会互动增加。终身组还表现出更多的主导型行为。与所有其他情况相比，受孕前和哺乳期的热量限制导致后代表现出增强且更有效的交配模式。受孕前和哺乳期组与部分（即使不是全部）其他热量限制组及对照组相比，插入频率降低、射精潜伏期缩短且射精频率更高，证明了这一点。与对照组相比，受孕前组的血清睾酮显著更高。这些发现表明，发育特定时期的热量限制可不同程度地改变成年后的社会行为表型和激素水平。
