利多卡因/丙胺卡因乳膏（复方利多卡因乳膏）与一种酒精类消毒剂对完整人体皮肤菌群抗菌性能的比较。
A comparison of the antimicrobial property of lidocaine/prilocaine cream (EMLA) and an alcohol-based disinfectant on intact human skin flora.
作者信息
Batai Istvan, Bogar Lajos, Juhasz Vera, Batai Reka, Kerenyi Monika
机构信息
Department of Anesthesia and Intensive Care, Pecs University, Pecs, Hungary.
出版信息
Anesth Analg. 2009 Feb;108(2):666-8. doi: 10.1213/ane.0b013e31818f887e.
BACKGROUND
The application of EMLA cream is indicated for topical anesthesia of the skin in connection with IV cannulation. Recently, we described that EMLA cream has an antibacterial effect in vitro.
METHODS
The impact of the local anesthetic lidocaine/prilocaine cream (EMLA) on intact human skin flora was compared to that of an alcohol-based skin disinfectant (Skinsept Pur). Samples were taken from 0 to 12 h after treatment.
RESULTS
The number of colony forming units (cfu) on the skin decreased significantly after both EMLA and Skinsept Pur treatment from 44.9 +/- 1.3 (42.4 +/- 7.0) to 0.9 +/- 0.17 (1.61 +/- 0.47) cfu/cm(2), respectively (mean +/- sem), at the first sampling time (1 h) and remained significantly below 0 h values for the study period. The cfu count was significantly lower with EMLA cream at 4, 6, and 12 h compared to Skinsept Pur.
CONCLUSION
EMLA cream has a longer bacteriostatic effect after early bactericidal impact compared to skin disinfection with Skinsept Pur.
背景
复方利多卡因乳膏（EMLA）用于静脉置管时的皮肤局部麻醉。最近，我们报道了EMLA乳膏在体外具有抗菌作用。
方法
将局部麻醉药利多卡因/丙胺卡因乳膏（EMLA）对完整人体皮肤菌群的影响与一种酒精基皮肤消毒剂（Skinsept Pur）进行比较。在治疗后0至12小时采集样本。
结果
在首次采样时间（1小时），EMLA和Skinsept Pur治疗后皮肤上的菌落形成单位（cfu）数量均显著下降，分别从44.9±1.3（42.4±7.0）降至0.9±0.17（1.61±0.47）cfu/cm²，并且在研究期间显著低于0小时的值。在4、6和12小时时，EMLA乳膏的cfu计数显著低于Skinsept Pur。
结论
与使用Skinsept Pur进行皮肤消毒相比，EMLA乳膏在早期杀菌作用后具有更长的抑菌效果。
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