van Vliet Mariska, von Rosenstiel Inès A, Schindhelm Roger K, Brandjes Desiderius P M, Beijnen Jos H, Diamant Michaela
Department of Paediatrics, Slotervaart Hospital, Amsterdam, the Netherlands.
Cardiovasc Diabetol. 2009 Jan 19;8:2. doi: 10.1186/1475-2840-8-2.
Differences in prevalence of cardiometabolic risk factors between different ethnic groups are largely unknown. We determined the variation in cardiometabolic risk profile according to ethnicity in a cohort overweight/obese Dutch children.
An oral glucose tolerance test was performed in 516 overweight/obese Dutch children of multi-ethnic origin, attending an obesity out-patient clinic of an urban general hospital (mean age 10.6 +/- 3.2; 55.2% boys). Anthropometric parameters and blood samples were collected, and the prevalence of (components of) the metabolic syndrome (MetS) and insulin resistance were determined in each ethnic group.
Major ethnic groups were Dutch native (18.4%), Turkish (28.1%), and Moroccan (25.8%). The remaining group (27.7%) consisted of children with other ethnicities. Turkish children had the highest mean standardized BMI compared to Dutch native children (P < 0.05). As compared to Moroccan children, they had a higher prevalence of MetS (22.8% vs. 12.8%), low HDL-cholesterol (37.9% vs. 25.8%), hypertension (29.7% vs. 18.0%) and insulin resistance (54.9% vs. 37.4%, all P < 0.05). Although Turkish children also had higher prevalences of forementioned risk factors than Dutch native children, these differences were not statistically significant. Insulin resistance was associated with MetS in the Turkish and Moroccan subgroup (OR 6.6; 95%CI, 2.4-18.3 and OR 7.0; 95%CI, 2.1-23.1, respectively).
In a Dutch cohort of overweight/obese children, Turkish children showed significantly higher prevalences of cardiometabolic risk factors relative to their peers of Moroccan descent. The prospective value of these findings needs to be established as this may warrant the need for differential ethnic-specific preventive measures.
不同种族群体中心血管代谢危险因素的患病率差异很大程度上尚不明确。我们在一组超重/肥胖的荷兰儿童中，根据种族确定了心血管代谢风险概况的差异。
对516名来自多民族的超重/肥胖荷兰儿童进行了口服葡萄糖耐量试验，这些儿童在一家城市综合医院的肥胖门诊就诊（平均年龄10.6±3.2岁；55.2%为男孩）。收集人体测量参数和血液样本，并确定每个种族群体中代谢综合征（MetS）及其（各组分）和胰岛素抵抗的患病率。
主要种族群体为荷兰本地人（18.4%）、土耳其人（28.1%）和摩洛哥人（25.8%）。其余群体（27.7%）由其他种族的儿童组成。与荷兰本地儿童相比，土耳其儿童的平均标准化BMI最高（P<0.05）。与摩洛哥儿童相比，他们的MetS患病率更高（22.8%对12.8%）、高密度脂蛋白胆固醇水平低（37.9%对25.8%）、高血压患病率高（29.7%对18.0%）以及胰岛素抵抗患病率高（54.9%对37.4%，所有P<0.05）。尽管土耳其儿童上述危险因素的患病率也高于荷兰本地儿童，但这些差异无统计学意义。在土耳其和摩洛哥亚组中，胰岛素抵抗与MetS相关（OR分别为6.6；95%CI，2.4 - 18.3和OR 7.0；95%CI，2.1 - 23.1）。
在荷兰超重/肥胖儿童队列中，土耳其儿童相对于摩洛哥裔同龄人，心血管代谢危险因素的患病率显著更高。这些发现的前瞻性价值有待确定，因为这可能需要采取不同的针对特定种族的预防措施。
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