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一名来自冈比亚的儿童因新型肺炎链球菌14型血清型的外源性再次感染而导致复发性脑膜炎。

Exogenous re-infection by a novel Streptococcus pneumoniae serotype 14 as a cause of recurrent meningitis in a child from The Gambia.

作者信息

Antonio Martin, Oluwalana Claire, Secka Ousman, Corrah Tumani, Howie Stephen, Adegbola Richard A

机构信息

Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia, Africa.

出版信息

Ann Clin Microbiol Antimicrob. 2009 Jan 20;8:3. doi: 10.1186/1476-0711-8-3.

DOI:10.1186/1476-0711-8-3
PMID:19154571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2633280/
Abstract

We report a case of an infant who experienced exogenous re-infection of Streptococcus pneumoniae serotype 14 as a cause of recurrent meningitis after apparently successful antibiotic treatment with ceftriaxone. eBURST analysis revealed that isolates from the two episodes of meningitis belonged to hypervirulent ST63 and ST3321 clonal complexes respectively.

摘要

我们报告了一例婴儿病例，该婴儿在接受头孢曲松抗生素治疗看似成功后，因14型肺炎链球菌再次发生外源性感染而导致复发性脑膜炎。eBURST分析显示，两次脑膜炎发作的分离株分别属于高毒力的ST63和ST3321克隆复合体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e80/2633280/5aab094b23de/1476-0711-8-3-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e80/2633280/cc882b221003/1476-0711-8-3-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e80/2633280/5aab094b23de/1476-0711-8-3-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e80/2633280/cc882b221003/1476-0711-8-3-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e80/2633280/5aab094b23de/1476-0711-8-3-2.jpg

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BMC Infect Dis. 2008 Jun 11;8:81. doi: 10.1186/1471-2334-8-81.
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Recurrent systemic pneumococcal disease and IRAK4 deficiency.复发性全身性肺炎球菌疾病与白细胞介素-1受体相关激酶4缺乏症
Pediatr Infect Dis J. 2007 Nov;26(11):1074; author reply 1074. doi: 10.1097/INF.0b013e318156fb93.
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Recurrent systemic pneumococcal disease in children.
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Pediatr Infect Dis J. 2007 Jun;26(6):480-4. doi: 10.1097/INF.0b013e31805ce277.
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Recurrent infection with genetically identical pneumococcal isolates in a patient with interleukin-1 receptor-associated kinase-4 deficiency.一名白细胞介素-1受体相关激酶-4缺乏患者反复感染基因相同的肺炎球菌分离株。
J Med Microbiol. 2007 Jun;56(Pt 6):863-865. doi: 10.1099/jmm.0.47046-0.
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Pneumococcal conjugate vaccine for childhood immunization--WHO position paper.用于儿童免疫的肺炎球菌结合疫苗——世界卫生组织立场文件
Wkly Epidemiol Rec. 2007 Mar 23;82(12):93-104.
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