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大剂量免疫球蛋白疗法是否适用于新生儿恒河猴溶血?一例因恒河猴(c + E)血型不合导致的溶血病成功病例。

Can high-dose immunoglobulin therapy be indicated in neonatal rhesus haemolysis? A successful case of haemolytic disease due to rhesus (c + E) incompatibility.

作者信息

Kubo S, Ariga T, Tsuneta H, Ishii T

机构信息

Department of Paediatrics, Hokkaido Central Hospital for Social Health Insurance, Sapporo, Japan.

出版信息

Eur J Pediatr. 1991 May;150(7):507-8. doi: 10.1007/BF01958434.

DOI:10.1007/BF01958434
PMID:1915504
Abstract

A male neonate with hyperbilirubinaemia and progressing anaemia due to rhesus (c + E) incompatibility received high dose intravenous gammaglobulin (ivIgG) therapy at 13 days of age. Clinical response to therapy was confirmed by a rapid decrease in serum bilirubin level, and with the prevention of a further decline of the haemoglobin level. No side-effects were noted. High dose ivIgG therapy could be an alternative to (exchange) blood transfusion in case of some haemolytic diseases of newborn.

摘要

一名因恒河猴血型(c + E)不相容而患有高胆红素血症并伴有进行性贫血的男婴在13日龄时接受了高剂量静脉注射丙种球蛋白(ivIgG)治疗。血清胆红素水平迅速下降以及血红蛋白水平进一步下降得到预防,证实了治疗的临床反应。未观察到副作用。对于某些新生儿溶血病,高剂量ivIgG治疗可能是(换血)输血的替代方法。

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Immunoglobulin for alloimmune hemolytic disease in neonates.新生儿同种免疫性溶血病用免疫球蛋白
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本文引用的文献

1
High-dose intravenous intact IgG infusion in refractory autoimmune hemolytic anemia (Evans syndrome).大剂量静脉输注完整免疫球蛋白治疗难治性自身免疫性溶血性贫血(伊文氏综合征)。
J Pediatr. 1985 Nov;107(5):744-6. doi: 10.1016/s0022-3476(85)80405-4.
2
Intravenous immunoglobulin for neonatal isoimmune thrombocytopenia.静脉注射免疫球蛋白治疗新生儿同种免疫性血小板减少症
Arch Dis Child. 1985 Jul;60(7):667-9. doi: 10.1136/adc.60.7.667.
3
Treatment of immune hemolytic anemia with gammaglobulin.用丙种球蛋白治疗免疫性溶血性贫血。
J Pediatr. 1987 May;110(5):817-8. doi: 10.1016/s0022-3476(87)80036-7.
4
High-dose intravenous immunoglobulin as the sole prenatal treatment for severe Rh immunization.大剂量静脉注射免疫球蛋白作为严重Rh血型免疫的唯一产前治疗方法。
N Engl J Med. 1988 Feb 25;318(8):519-20. doi: 10.1056/NEJM198802253180816.
5
Rhesus haemolytic disease treated with high-dose intravenous immunoglobulin.大剂量静脉注射免疫球蛋白治疗恒河猴溶血病。
Lancet. 1985 May 18;1(8438):1153. doi: 10.1016/s0140-6736(85)92451-1.
6
Clinical uses of intravenous immunoglobulins.静脉注射免疫球蛋白的临床应用。
Ann Intern Med. 1990 Feb 15;112(4):278-92. doi: 10.7326/0003-4819-112-4-278.