Greenough A
Children Nationwide Regional Neonatal Intensive Care Centre, King's College Hospital, London, UK.
Eur J Pediatr. 1999 Sep;158(9):689-93. doi: 10.1007/s004310051180.
The incidence of rhesus haemolytic disease has been markedly reduced. Affected infants who have had intrauterine transfusions suffer a late hyporegenerative anaemia. Postnatal haemolysis and hence treatment for hyperbilirubinaemia is less commonly needed. Optimal phototherapy reduces the need for postnatal exchange transfusions, but data on the efficacy of inhibitors of bilirubin production such as haem oxygenase inhibitors or immunoglobulin are less secure. Even hydropic infants have less than 20% mortality and bilirubin encephalopathy is uncommon. There is, however, very limited information on the long-term outcome of infants with rhesus haemolytic disease. Multicentre collaboration is required to test strategies to improve the management of affected individuals further and to provide meaningful data on their prognosis.
恒河猴溶血病的发病率已显著降低。接受过宫内输血的患病婴儿会出现晚期再生低下性贫血。产后溶血以及因此对高胆红素血症的治疗需求较不常见。最佳光疗减少了产后换血输血的需求，但关于胆红素生成抑制剂（如血红素加氧酶抑制剂或免疫球蛋白）疗效的数据不太可靠。即使是水肿胎儿的死亡率也低于20%，胆红素脑病并不常见。然而，关于恒河猴溶血病婴儿长期预后的信息非常有限。需要多中心合作来测试进一步改善对患病个体管理的策略，并提供有关其预后的有意义数据。
